cancer cellchemotherapyDNA damagingSummary This chapter contains section titled: Mechanism of p53 Tumor Suppression and Rationale for p53 Gene Therapy Gene Replacement in Combination with Conventional DNA Damaging Agents in NSCLC Clinical Trials of Tumor Suppressor Gene Replacement Combined with Chemotherapy ...
Targeted therapy for oncogenic addiction involves identification of the oncogene specific to a cancer and inhibiting the activity of the proteins it encodes. Most of the targeted therapies for oncogenic addiction are small-molecule inhibitors, which bind to cell proteins and block their activity. Target...
000 cancer-related deaths in 2018. Surgery and chemotherapy have long been the first choices for cancer patients. However, the prognosis of CRC has never been satisfying, especially for patients with metastatic lesions. Targeted therapy is a new optional approach...
In this study, we tested Rad51 promoter-based targeted cancer therapy in vivo. A major challenge to applying gene therapy in vivo is delivery. We used the clinically tested polyethylenimine-derived in vivo-jetPEI transfection reagent (Polyplus-Transfection, Illkirch, France) for nanoparticle-mediated...
An of the article "Targeted gene silencing for cancer treatment," by José S. Ramalho, Sérgio Simões is presented. da,Silva,Lígia,... - 《Bmc Proceedings》 被引量: 0发表: 2010年 Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy The deoxyribonuc...
Data from certain leukemias as well as brain and breast cancer indicate that there is a small population of tumor cells with ‘stem cell’ characteristics and the capacity for self-renewal. The self-renewing cells have many of the properties of normal st
Hine CM, Seluanov A, Gorbunova V (2012) Rad51 promoter-targeted gene therapy is effective for in vivo visualization and treatment of cancer . Mol Ther... CM Hine,A Seluanov,V Gorbunova - 《Molecular Therapy the Journal of the American Society of Gene Therapy》 被引量: 37发表: 2012年 ...
"I saw the potential of targeted therapy in China. And more importantly, I believe it is the future for cancer treatment," Zheng said.
HER2 targeted therapies in different cancer Breast cancer Antibodies The introduction of HER2-targeted therapy has revolutionized the landscape of breast cancer treatment. The currently approved HER2 monoclonal antibodies (mAb) for breast cancer treatment include trastuzumab and pertuzumab. Trastuzumab (Hercept...
HER2 targeted therapies in different cancer Breast cancer Antibodies The introduction of HER2-targeted therapy has revolutionized the landscape of breast cancer treatment. The currently approved HER2 monoclonal antibodies (mAb) for breast cancer treatment include trastuzumab and pertuzumab. Trastuzumab (Hercept...