Systemic screening and alanine substitution further identified a 25-residue leucine motif ([DE]XXXL[LI]) containing an axonal targeting sequence within the α4 loop and a 48-residue dileucine and tyrosine motif (YXXØ) containing a dendritic targeting sequence from the α7 loop. These results ...
(A) Structure ofGhTORgenes. Lines represent introns and the solid black rectangles signify exons. (B) Comparison of cotton TOR protein sequences with that from other organisms. Each value indicates the percentage of identity with the corresponding domain sequences of GhTOR1. The number in bracke...
摘要: Motivation: It is commonplace to predict targets of transcription factors (TFs) by sequence matching with their binding motifs. However, this ignores the particular condition of the cells. Gene ex ...关键词: Humans Estradiol Transcription Factors Receptors, Estrogen Oligonucleotide Array Sequence...
Find siRNA sequences - Standard searchInstructions:1. Enter your siRNA name for reference (optional) 2. Paste the sequence of your target gene. (Spaces and numbers will be ignored) 3. Enter the desired motif size (21 nt by default). 4. If you want to increase the siRNA's specificity ...
First, the 5'-NGG protospacer adjacent motif (PAM) sequence must be located adjacent to the target sequence. Second, the target sequence should be specific within the entire genome in order to avoid off-target editing. CRISPRdirect enables users to easily select rational target sequences with ...
Reinaet al.computationally reengineered a small protein–protein interaction motif, thePDZ domain, to bind novel peptide target sequences[48••]. The first target was a naturally occurringpeptide sequenceat the C-terminus of a kinesin-like molecule; the design goal was to create a ‘sensor...
Aminopeptidase N Is a Receptor for Tumor-homing Peptides and a Target for Inhibiting Angiogenesis Phage that display a surface peptide with the NGR sequence motif home selectively to tumor vasculature in vivo. A drug coupled to an NGR peptide has more p... R Pasqualini,E Koivunen,R Kain,.....
L. Hyperediting of multiple cytidines of apolipoprotein B mRNA by APOBEC-1 requires auxiliary protein(s) but not a mooring sequence motif. J. Biol. Chem. 271, 11506–11510 (1996). Article CAS Google Scholar Powell, L. M. et al. A novel form of tissue-specific RNA processing produces...
sequence with little homology to existing sequences, 1d motifs derived from class IV and XII 3d motifs, which are not found in any nonNAD(P)-binding proteins, can be used to annotate NAD(P)-binding proteins, whereas the II_NADP motif, which was not found in nonphosphate-binding proteins...
(all accessible chromatin sequences, not limited to DAPs). The HOMER software package was used to identify enrichment of TF binding sites (TFBS) within the subset of LOAD CCANs for each cell subtype for TFs that were expressed in ≥ 10% of the corresponding cell subtype (Fig.6a, ...