Such ectopic accumulation of lipid, together with the entopic accumulation, is thought to sbe related to the pathogenesis of insulin resistance. Much evidence thus suggests that the extent of lipid deposition in skeletal muscle, a major target organ of insulin, is highly correlated with whole-body...
International Journal of Obesity Related Metabolic Disorders , 4 , S15 – S20 .Schunkert H. Obesity and target organ damage: the heart. Int J Obes Relat Metab Disord. 2002;26 Suppl 4:S15–20.Schunkert H. Obesity and target organ damage: the heart. Int J Obes Relat Metab Disord. 2002;...
After migration to these tissues, immune cells produce a variety of cytokines and chemokines that perpetuate the immune response and contribute to tissue destruction. This destruction leads to irreversible damage and loss of function of the target organ. In RA, the joints are irreversibly damaged, ...
G Ken - 《Journal of the National Cancer Institute》 被引量: 321发表: 2001年 Immunosuppressive Agents in Clinical Trials Transplantation Many new agents are in or near clinical trials in organ transplantation. The small molecule antibioticlike drugs are inhibitors of key enzymes in T-cell si......
Sirolimusis used for the prevention of organ rejection in kidney allograft recipients (initially in combination withciclosporinand a corticosteroid and then with a corticosteroid only). Mode of Administration Oral. Pharmacological Effects Sirolimus binds to theimmunophilin, FK-binding protein-12 (FKBP-12...
Insulin resistance (IR) is related to arterial hypertension and target organ damage. Hypertensive individuals exhibiting a diminished nocturnal blood press... EJ Diamantopoulos,E Andreadis,G Tsourous,... - 《Clinical & Experimental Hypertension》 被引量: 17发表: 2006年 High Prevalence of Isolated No...
Diabetes mellitus is a complex disease characterized by the loss or dysfunction of insulin-producing beta cells in the islets of Langerhans, a specialist “micro-organ” in the pancreas that controls systemic blood sugar levels. Diabetes complications, such as chronic high blood sugar, systemic metab...
Our results provide strong evidence that fetuin-A supplementation at the time of injury (e.g., ischemia-reperfusion injury in diverse organ systems) could be a promising therapeutic approach against hypoxia-induced mineral stress and fibrotic tissue remodeling, particularly in conditions associated with...
Organ-on-a-chip microengineering for bio-mimicking disease models and revolutionizing drug discovery Tanvir Ahmed, in Biosensors and Bioelectronics: X, 2022 5.3 Preclinical screening & testing: PK/PD After identifying candidate molecules & targets, PK and PD studies are conducted. PK studies examine ...
Heart sections of empa and vehicle-treated rats showed no differences in cardiac perivascular fibrosis. Students t-test, *** p < 0.001; data expressed as mean ± SEM. Full size image Discussion We investigated the combined effects of hypertension and hyperglycemia on end-organ damage, ...