Rodent adipose tissue and cells represent the targets exhibiting the most prominent insulin sensitivity (i.e., lowest EC/IC50) and responsiveness (i.e., highest fold stimulation/inhibition above basal) of the relevant insulin signaling cascades (e.g., insulin receptor activation) and metabolic end...
The STP recommends that all target tissues be examined from all control animals and all animals in the highest-dose group lacking the treatment-related finding to confirm the NOEL. They further suggest that in some rodent studies, examination of target tissues in a subset (50% or more) may ...
To determine whether impaired Akt (protein kinase B or rac) activation contributes to insulin resistance in vivo, we examined the expression, phosphorylation, and kinase activities of Akt1 and Akt2 isoforms in insulin target tissues of insulin-resistant obese Zucker rats. In lean rats, insulin (10...
1. 组织 肌肉骨骼超音波的标的组织(target tissues)包括:骨骼肌、肌腱、韧带、关节囊、周边神经、皮下脂肪、骨骼表面之骨膜(periost… tw.myblog.yahoo.com|基于7个网页 2. 目标组织 为了达到这个目标,适当的治疗剂量与投药间隔,都必须很准确地送到目标组织(target tissues),而且必须注意有效剂量及避免 … ...
tightly regulated; under hyperglycaemic conditions, the pancreatic hormone insulin promotes the translocation of glucose transporters—mainly GLUT4 (SLC2A4)—from intracellular vesicles to the plasma membrane of adipose and muscle tissues, thus promoting glucose uptake and normalizing circulating glucose ...
Our study paves the way to therapeutic approaches mitigating mineral stress-induced inflammation and damage, principally applicable to all soft tissues.Similar content being viewed by others Neonatal hyperoxia exposure leads to developmental programming of cardiovascular and renal disease in adult rats ...
Insulin-degrading enzyme (IDE) is an evolutionarily conserved neutral thiol metalloprotease expressed in all mammalian tissues whose biological role is not... IV Kurochkin - 《Febs Letters》 被引量: 138发表: 1998年 Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughpu...
The outer periphery of the insulin action for target tissue 翻译结果2复制译文编辑译文朗读译文返回顶部 role of insulin peripheral target organizations; 翻译结果3复制译文编辑译文朗读译文返回顶部 Peripheral role of insulin target tissues 翻译结果4复制译文编辑译文朗读译文返回顶部 ...
Skeletal muscle, liver, and adipose tissue are major insulin responsive target organs that also express androgen receptor. Testosterone (T) plays a role in maintaining normal insulin sensitivity in men but its effects on insulin target tissues are not fully understood. Our previous study showed that...
Licorice is also a unique "guide drug" in traditional CMF to lead the active constituents in herbs to their target tissues and organs56. Liquiritin, our selected representative ingredient of Glycyrrhiza uralensis, was validated to alleviate arrhythmia induced by aconitine in this research. The ...