Target for cancer therapy: proliferating cells or stem cells. Leukemia 2006;20:385-391.Blagosklonny MV (2006) Target for cancer therapy: proliferating cells or stem cells. Leukemia 20:385–391. doi: 10.1038/sj.leu.2404075Blagosklonny MV. (2006). Target for cancer therapy: proliferating ...
Pathways upstream of TOR are frequently activated in cancer. This can be through increased activity of phosphatidylinositol-3-kinase–AKT or kinases that regulate TSC2, or through mutations that inactivate TSC proteins. The TOR pathway is also upregulated in many human cancers and oncogenic transforma...
About this article Cite this article Bjornsti, MA., Houghton, P. The tor pathway: a target for cancer therapy. Nat Rev Cancer 4, 335–348 (2004). https://doi.org/10.1038/nrc1362 Download citation Issue Date01 May 2004 DOIhttps://doi.org/10.1038/nrc1362 Springer Nature LimitedAccess...
or alternatively cancer stem cells or tumor-initiating cells, has received considerable recent interest. CICs represent a subpopulation of transformed cells, distinct from more “differentiated” tumor cells, and are thought to be responsible for tumor organization, maintenance and progression, and resista...
43. Baud V, Karin M: Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 2009, 8:33-40.Lysophosphatidic acid up-regulates expression of interleukin-8and-6in granulosa-lutein cells through its ... SU Chen,CH Chou,H Lee,... - Endocrine Society 被引...
Tests inbreast cancer cellsin mice have proved promising. "Our studies unravel a novel, hitherto unrecognized, mechanism for the tumour-suppressive role of a plasma membrane transporter independent of its transport function," he says. To aide in the dissemination of this research, theBiochemical Jour...
A new target for cancer therapy has been identified by Monash University scientists investigating the cell signalling pathways that turn on a gene involved in cancer development. A team led by Associate Professor Jun-Ping Liu, from the Department of Immunology, has identified two proteins that are...
Metastatic cancer stem cells: a new target for anti-cancer therapy? Over the past few years, supporting evidence for the cancer stem cell hypothesis has been provided for an increasing number of tumor entities. According to... PC Hermann,SL Huber,C Heeschen - 《Cell Cycle》 被引量: 171发表...
identified glutaminolysis as a crucial pathway for cell growth downstream of NOTCH1. Knockout of GLS led to significant anti-leukemic effects, which is further enhanced by anti-NOTCH1 therapy in NOTCH1-induced T-ALL.61 Unlike GLS, the exact role of GLS2 in cancer is still controversial and ...
targetingcancerstemcellpathwaysfortherapy462020signaltransducttargetther REVIEWARTICLEOPEN Targetingcancerstemcellpathwaysforcancertherapy LiqunYang 1,2 ,PengfeiShi 1,2 ,GaichaoZhao 1,2 ,JieXu 1,2 ,WenPeng 1,2 ,JiayiZhang 1,2 ,GuanghuiZhang 1,2 ,XiaowenWang 1,2 , ZhenDong 1,2 ,FeiChen 3 and...