6.Do K, Doroshow JH, Kummar S. Wee1 kinase as atarget for cancer therapy. Cell Cycle. 2013 Oct 1;12(19):3159-64. doi:10.4161/cc.26062. Epub 2013 Aug 26. PMID: 24013427; PMCID: PMC3865011. 7.Moiseeva TN, Qian C, Sugitani N, Osmanbeyoglu HU,Bakkenist CJ. WEE1 kinase inhibit...
Shivaani KummarDo K, Doroshow JH, Kummar S. Wee1 kinase as a target for cancer therapy. Cell Cycle 2013; 12: 3159-3164.Do K, Doroshow JH, Kummar S. Wee1 kinase as a target for cancer therapy. Cell Cycle 2013; 12:3159-64; PMID: 24013427; http://dx.doi.org/10.4161/cc.26062...
然而基因毒性应激、烷基化剂、辐射等刺激导致DNA发生单链或双链断裂,DNA损伤反应信号通路(DNA damage response signaling pathways,DDR)被激活[6],从而激活下游共济失调毛细血管扩张激酶(ataxiat elangiectasia-mutated kinase,ATM)信号通路或...
Wee1 kinase as a target for cancer therapy. Cell Cycle 12, 3348–3353 (2013). Article CAS Google Scholar Schwob, E. The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79, 233–244 (1994). Article CAS PubMed Google Scholar Verma, R...
10、Do K, DoroshowJH, Kummar S. Wee1 kinase as a target for cancer therapy. Cell cycle. 2013 Oct1;12(19):3348-53. 11、Ashwell S.Checkpoint kinase and Wee1 inhibitors as anticancer therapeutics. InDNA repairin cancer therapy 2012 Jan...
Kummar Wee1 kinase as a target for cancer therapy Cell Cycle, 12 (19) (2013), pp. 3159-3164 Google Scholar [14] J. Lee, A. Kumagai, W.G. Dunphy Positive regulation of Wee1 by Chk1 and 14-3-3 proteins Mol. Biol. Cell, 12 (3) (2001), pp. 551-563 CrossrefView in Scopus...
Silencing of the Apoptosis associated Tyrosine Kinase gene (AATK) has been described in cancer. In our study, we specifically investigated the epigenetic inactivation of AATK in pancreatic adenocarcinoma, lower grade glioma, lung, breast, head, and neck
Kummar Wee1 kinase as a target for cancer therapy Cell Cycle, 12 (2013), pp. 3159-3164, 10.4161/cc.26062 Google Scholar 19 T.N. Moiseeva, C. Qian, N. Sugitani, H.U. Osmanbeyoglu, C.J. Bakkenist WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in ...
WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe [J]. Clin Cancer Res, 2011, 17(13): 4200-4207. [16] Curtin N J. DNA repair dysregulation from cancer driver to therapeutic target [J]. Nat Rev Cancer, 2012, 12(12): 801-817. [17] Vriend L...
We show that PD0166285, a small molecule WEE1 kinase inhibitor, can abrogate the G2 checkpoint in OS cells, pushing them into mitotic catastrophe and thus sensitizing OS cells to irradiation-induced cell death. This suggests that WEE1 inhibition may be a promising strategy to enhance the radiot...