Wee1-like protein kinase 2 (WEE2) is an oocyte-specific protein tyrosine kinase involved in the regulation of oocyte meiotic arrest in humans. As such, it has been proposed as a candidate for non-hormonal female contraception although pre-clinical models have not...
THE wee1 + gene is a mitotic inhibitor controlling the G2 to M transition of the fission yeast Schizosaccharomyces pombe 1 and encodes a protein kinase with both serine- and tyrosine-phosphorylating activities 2 . We have cloned a human gene ( WEElHu ) similar to weel + by transcomplementati...
REGULATION OF HUMAN WEE1-LIKE SERINE/THREONINE PROTEIN KINASEKöhler, Rainer H.
b) a polynucleotide comprising the sequence of SEQ ID NO: 1 or SEQ ID NO: 5; c) a polynucleotide the sequence of which deviates from the polynucleotide sequences specified in (a) due to the degeneracy of the genetic code encoding a polypeptide of serine / threonine protein kinase WEE1...
Wee1 protein kinase represses CDK1 required for G2/M transition. The mouse wee1 promoter contains multiple CACCC-boxes between 鈭拋0 2306 and + 1 that can bind to Kr眉ppel-like factor 3 (KLF3) transcriptional repressor. We found that increasing amounts of intracellular KLF3 decreased ...
UTR contains 13 AUUUA pentamers, which have been characterized as determinants of mRNA lability; and the N-terminal domain of the predicted WEE1S.purp polypeptide is enriched in STP-containing, potential kinasetarget sites, as well as high-value 'PEST' sequences, associated with protein ...