Uptake of ACE is increased in the lipid pool of cancer cell membranes and may be further enhanced by hypoxia. This biological information is used to delineate a GTV within the CTV covering the whole prostate. The high radiation dose is boosted only to the GTV using simultaneous integrated ...
Based on the work of these scientists, genetic engineering wasdeveloped in 1973. This method is the foundation of modern biotechnology practices and recent advances. It enabled the first direct manipulation of plant and animal genomes, which is the complete set of genes present in a cell. GMOs ...
27.2.2Cell-targeting peptides Cell-targeting peptides (CTPs) are small peptides of 3–10 amino acids that are specific for certain cells or tissues[29]. CTPs have high specificity andaffinity for particular cell lines or cell interactions[30]. Monoclonal antibodies have been generated for target...
[ 6 ]. in this study, we adopt a broad definition of tf that includes the cofactors and other transcription initiation factors. the pivotal role of tfs in development and cell identity determination is highlighted by the induced pluripotent stem cell (ipsc) technology [ 7 , 8 ] and trans-...
and therefore more stringent fractionation might be required, together with the application of sophisticated microscopic imaging, MS and radiometric methods of detection and quantification6. An accurate and quantifiable pillar 2 (measurement of target engagement inside the cell) also, by definition, provid...
Deciphering the genetics of FHL has contributed towards our understanding of the cell biology of hyperinflammatory responses and hemophagocytic lymphohistiocytosis accompanying pathological conditions such as cancer and viral infections.doi:10.4236/cellbio.2015.43005Bor Luen Tang...
Alzheimer’s disease (AD) and Parkinson’s disease (PD), two common irreversible neurodegenerative diseases, share similar early stage syndromes, such as olfaction dysfunction. Yet, the potential comorbidity mechanism of AD and PD was not fully elucidate
Disclosed herein is a method to determine the biological function(s) of a target gene in a cell, the steps of which involve separately culturing a first population and a second population of the cell under same culturing conditions, the first population of the cell differing from the second po...
and the global interpretation of the results obtained with other biochemical and cell biology methods, as well as possibly opening new avenues of study to decipher the mechanism of action of new drugs. Similar content being viewed by others
The mechanistic target of rapamycin (mTOR) network is an evolutionarily conserved signaling hub that senses and integrates environmental and intracellular nutrient and growth factor signals to coordinate basic cellular and organismal responses, such as cell growth, proliferation, apoptosis, and in...