It's interesting that there are so many different meanings for target cells. Are there any cases where the target cells are defective? It seems like a lot of other cells depend on the job they do. InfoBloom, in your inbox Our latest articles, guides, and more, delivered daily. ...
the present study identified a subset of fibroblasts and smooth muscle cells which are the major constituents of organ stroma neither proliferative nor senescent in tissues of the elderly, which we termed “mid-old status” cells. Upregulation of pro-inflammatory genes...
do not have any functional meaning. Rather, such short-term plasticity plays an essential role in determining the cut-off frequency of a synapse, thus limiting the content of information flow at a specific pathway [32,30,42–45]. The most important consequences of the higher...
Tissue mononuclear phagocytes (MNP) are specialised in pathogen detection and antigen presentation. As such they deliver HIV to its primary target cells; CD4 T cells. Most MNP HIV transmission studies have focused on epithelial MNPs. However, as mucosal trauma and inflammation are now known to be...
Cancer cells are well known for a series of patterns including constant proliferative signaling, growth suppressor’s avoidance, resistance to cell death, replicative immortality, high angiogenesis, reprogrammed energy metabolism, immune-mediated destruction, invasion, and metastasis, by which they can surp...
aptamer vector was validated in Cos cells. The substitution of the theophylline-binding aptamer for the P6 region of the shRNA1-intron led to less efficient silencing, prompting us to investigate the activity of the shRNA1-intron-aptamer when the ligand for the aptamer was present in the ...
63]. Changing the polarity of stimulation reverses the polarization in each given compartment. For example, it is correct to say that “anodal” DCS will depolarize the somas of most cortical pyramidal neurons while recognizing that other compartments of those neurons and of neighboring cells will ...
As an intestinal nutrient, butyrate promotes the regeneration of intestinal cells to repair the intestinal mucosa, initiates the differentiation and apoptosis of normal intestinal cells, stimulates the synthesis of intestinal mucin glycoprotein, and strengthens the protective effect of the mucous layer. ...
cells (BMDCs) or tissue-resident cells to reprogram the microenvironment of distant target organs to make it hospitable for CTC survival and colonization. The induction of primary tumors is purposeful rather than random, meaning that the CTCs have already confirmed their destination and prepared their...
Computational methods that model how gene expression of a cell is influenced by interacting cells are lacking. We present NicheNet ( https://github.com/saeyslab/nichenetr ), a method that predicts ligand–target links between interacting cells by combini