Cancer Chemotherapy Laurie D.DeLeve, inDrug-Induced Liver Disease (Third Edition), 2013 Tamoxifen Tamoxifen, a nonsteroidal drug with antiestrogenic and estrogenic properties, is widely used in the chemoprevention of breast cancer. Reported liverinjuryfromtamoxifenincludesnonalcoholic fatty liver disease(...
chemotherapy; or if you also useanastrozoleorletrozole. Taking tamoxifen may increase your risk of uterine cancer, liver cancer, stroke, or a blood clot in the lung, which can be fatal. Talk with your doctor about your own risks. Do not breastfeed while using tamoxifen,and for at least 3...
When tamoxifen is coadministered with chemotherapy, there may be a further increase in the incidence of thromboembolic effects. For treatment of breast cancer, the risks and benefits of tamoxifen should be carefully considered in women with a history of thromboembolic events. In a small substudy (...
For the estrogen receptor positive (ER+) subtype, the efficacy of adjuvant endocrine therapy is definitive, but that of adjuvant chemotherapy is controversial. Methods In order to evaluate the effect of adding doxorubicin (A) and cyclophosphamide (C) to tamoxifen (TAM) (ACT) on the overall ...
In 1989 the first report from a large prospective randomised trial showed a significant increase of endometrial carcinoma among women treated with adjuvant tamoxifen. This effect may be linked to the somewhat paradoxical estrogenic properties of tamoxifen. The endometrial effects should be considered in ...
excluded. The corresponding reduction in mortality was 6% (NS). The effects of about 5 years of NOLVADEX (tamoxifen citrate) on recurrence and mortality were similar regardless of age and concurrent chemotherapy. There was no indication that doses greater than 20 mg per day were more effective....
A pilot study of AFL-T (doxorubicin, 5-fluorouracil, leucovorin, and tamoxifen) combination chemotherapy for hormone-refractory prostate cancer. Tamoxifen had been used to treat advanced prostate cancer with limited success. In vitro data suggested that tamoxifen could enhance the cytotoxic effect o....
. Also, polymer-coated gold nanoparticles (P-AuNPs) have different applications in biomedicine and cancer chemotherapy; their surface is covered with biocompatible and biodegradable polymers, including heparin, hyaluronic acid, chitosan, xanthan gum, PEG, polystyrene sulfonate, polyethyleneimine, etc. (...
Patients with CYP2D6 poor-, intermediate-, or normal/intermediate-metabolizer phenotypes (activity scores of 0–1): Some experts state that 40 mg daily may be considered. (See Pharmacogenomic Considerations for Tamoxifen Therapy of Breast Cancer under Uses.)...
chances of survival. Even though patients' therapy options for hormone receptor-positive tumours have significantly improved, including anti-estrogen-based therapies and others such as CDK4/6 inhibitors, for patients with TNBC, there are no other viable therapeutic choices available besides chemotherapy....