The drug tamoxifen is widely used in the chemotherapy of breast cancer but its action is not explained completely by its anti-oestrogen properties. We now present evidence indicating that it is also a potent inhibitor of eukaryotic protein synthesis as demonstrated in Xenopus oocytes, intact ...
Princess Kate revealed in a video today that she is getting "preventative chemotherapy" for her form of cancer. Here's everything we know about the treatment.
Often the gains made are at a price. Discomfort and side effects are the patients’ constant companions during rigorous chemotherapy regimens. Unfortunately, objective and complete responses invariably turn to rapidly growing drug-and radiation-resistant disease....
Tamoxifen has been the mainstay of hormonal treatment. However, new aromatase inhibitors challenge tamoxifen as the first line therapy in postmenopausal women. Trastuzumab with conventional chemotherapy is the standard of care in patients with... KH Jung 被引量: 2发表: 2009年 ...
By doing so, we expected to have available a small set of robust biomarkers for the breast cancer subtype where paclitaxel chemotherapy is more relevant. The 117 samples from Set 1 were stained with the 11 antibodies against the potential biomarkers, and an H-score was calculated. The H-...
Tamoxifen agonism and E2 hypersensitivity, together with the RNA-seq and ER ChIP-seq data, suggested that neurofibromin may function as a ligand-dependent co-repressor for ER transcriptional activity. Consistent with this postulate, there are two consensus co-repressor motifs in neurofibromin, desig...
It was found that increased SUMOylation significantly promoted the self-renewal and chemotherapy resistance of CSCs in colon cancer [35]. And Neddylation could regulate the proliferation and differentiation of CSCs in lung cancer and colon cancer [36]. However, the roles of ubiquitin-like proteins...
Triple-negative breast cancer (TNBC) has a poor clinical outcome, due to a lack of actionable therapeutic targets. Herein we define lysosomal acid lipase A (LIPA) as a viable molecular target in TNBC and identify a stereospecific small molecule (ERX-41) that binds LIPA. ERX-41 induces endopl...
With increasing recognition of evading immunological destruction as a hallmark of cancer acquired during its development[1], immunotherapy has emerged as a novel and important pillar of cancer treatment in addition to surgery, radiation, chemotherapy, and targeted therapy. Instead of directly killing can...
A combination of cisplatin and pemetrexed is the current first-line chemotherapy regimen for MM patients.3 Doxorubicin (Dox) was the first successful chemotherapeutic drug tested in MM and is currently administered in combination with other treatment strategies.4, 5 Recent focus for MM treatment ...