Bramwell VH, Pritchard KI: Tamoxifen added to adjuvant chemo- therapy in premenopausal women with early breast cancer: Is it standard practice or still a subject for study? Eur J Cancer 35:1625-1627, 1999Bramwell VHC, Pritchard KI. Tamoxifen added to adjuvant chemotherapy in premenopausal women...
Researchers have shown via ongoing studies on M2-like macrophages that their potential to interact with tumor cells in a direct or indirect way, influencing anticancer medication therapeutic tolerance (Table 2) like chemotherapy, targeted therapy, and immunotherapy41. The possible regulatory mechanisms b...
PEITC has also been found to enhance the sensitivity of the breast cancer cells to radiotherapy and Adriamycin (doxorubicin). AITC has also been shown to reduce Adriamycin-induced heart damage (cardiomyopathy) in a rat model of chemotherapy....
Neurofibromin is a co-repressor of estrogen receptor (ER), therefore loss enhances ER transcriptional activity. Loss-of-function mutations in the NF1 gene promote tamoxifen agonism and estrogen deprivation resistance. Although ER+ NF1-depleted cells are initially responsive to fulvestrant, a selective...
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N. Engl. J. Med. 351, 2817–2826 (2004). Article CAS Google Scholar Huang, C. et al. Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma. ...
Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 10-year analysis of the ATAC trial. Lancet Oncol. 2010;11:1135–41. https://doi.org/10.1016/S1470-2045(10)70257-6. Clinical Trial Randomized Controlled Trial Research Support, Non-U.S. Gov't. Article...
Anavar is a prescription drug commonly prescribed for treating breast cancer patients who undergo chemotherapy. It has also been found to increase the effectiveness of other drugs such as tamoxifen. Natural steroids are safe and effective alternatives to performance enhancers. They contain only 100% ...
translocation. FAF1 also directly binds IKKβ, thereby inhibiting the NFκB pathway. AURKA phosphorylates FAF1 at S289 and S291, which allows phosphorylated FAF1 to degrade AURKA. (C) AURKA-ERα feedback loop confers tamoxifen resistance. Estrogen binding to ERα results in ERα dimerization ...
Patients' CD34+ hematopoietic stem/progenitor cells (HSPCs) are utilized in this novel therapy, genetically modified with a lentiviral vector containing functional ARSA cDNA. A chemotherapy conditioning cycle precedes the reinfusion of gene-corrected cells into the patients.The complex autoimmune disorder...
26 Hormone receptor–positive, HER2-negative breast cancers were far less likely to exhibit a pCR to preoperative chemotherapy26; however, some patients may be offered NET alone.24 Several studies have looked at baseline levels of Ki-67 as a biomarker for NET and found conflicting results. ...