TAK-243 (MLN7243) TAK-243 (MLN7243) is a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE) with an IC50 of 1 ± 0.2 nM in the UBCH10 E2 thioester assay. It has minimal inhibitory activity in a panel of kinase and r ...
TAK-243CAS号: 1450833-55-2分子式: C19H20F3N5O5S2分子量: 519.52描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究) 产品描述 描述 TAK-243 is a potent and selective ubiquitin-like modifier activating enzyme 1 (UBA1) inhibitor. 纯度 98% 储存/保存方法 Store at ...
TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM). TAK-243 blocks ubiquitin binding and disrupts mono-ubiquitin signaling as well as overall protein ubiquitination. TAK-243 exhibits antitumor activity and promotes apoptosis. ...
描述 TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM). TAK-243 blocks ubiquitin binding and disrupts mono-ubiquitin signaling as well as overall protein ubiquitination. TAK-243 exhibits antitumor activity and promotes apoptosis. 体外活性 方法:7 种骨髓...
TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activatingenzyme,UAE (UBA1)inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogatesNF-κ...
TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates...
A UAE inhibitor 此产品仅用于科学研究,我们不为任何个人用途提供产品和服务 库存:现货 可选规格 包装 5mg 10mg 数量 确认取消 ￥1490-2420 包装 价格 促销价 数量 5mg ￥1862.00 1490.00 -+ 10mg ￥3025.00 2420.00 -+ 已选0种0瓶 金额:￥0.00
TAK-243是一种有效的选择性泛素样修饰因子激活酶1(UBA1)抑制剂。 CAS:1450833-55-2 分子式:C19H20F3N5O5S2 分子量:519.52 纯度:98% 存储:Store at -20°C Background: TAK-243 is a potent and selective ubiquitin-like modifier activating enzyme 1 (UBA1) inhibitor. ...
[3]. Samir H. Barghout, et al. TAK-243 Is a Selective UBA1 Inhibitor That Displays Preclinical Activity in Acute Myeloid Leukemia (AML). Blood 2017, 130:814. 品牌介绍: • MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物; ...
TAK-243, also known as MLN7243 and AOB87172, is a small molecule inhibitor of ubiquitin-activating enzyme (UAE), with potential antineoplastic activity. UAE inhibitor MLN7243 binds to and inhibits UAE, which prevents both protein ubiquitination and subsequent protein degradation by the proteasome. ...