5. Rugo HS, et al. Capivasertib and fulvestrant (F) for patients (pts) with aromatase inhibitor (AI)-resistant HR+/HER2- advanced breast cancer (ABC): second progression-free survival (PFS2) and time to first subsequent chemotherapy (TFSC) in the CAPItello-291 trial. 2024 ESMO BC. 183...
PI3K/mTOR Inhibitor-2 PI3K/mTOR Inhibitor-2是一种有效的双重泛PI3K/mTOR抑制剂,具有抗肿瘤活性。 PI-103 PI-103 是一种多靶点 PI3K 抑制剂,在无细胞试验中作用于p110α/β/δ/γ的IC50为2 nM/3 nM/3 nM/15 nM,对 mTOR/DNA-PK的作用较小,IC50为30 nM/23 nM。PI-103 可诱导小鼠T细胞淋巴瘤的凋...
对于既往经CDK4/6抑制剂治疗后伴PIC3CA突变的HR阳性HER-2阴性晚期乳腺癌患者,BYLieve研究首次证实,CDK4/6抑制剂治疗后,接受Alpelisib联合芳香化酶抑制剂(aromatase inhibitor, AI)或氟维司群均可获益。同时,既往CDK4/6抑制剂治疗持续时...
41.Mandal M, Kim S, Younes MN, Jasser SA, El-Naggar AK, Mills GB, Myers JN. The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells.Br J Cancer. 2005;92:1899-1905.[PubMed] ...
关键词 胰腺炎; 磷酸肌醇3-激酶类; 蛋白质丝氨酸苏氨酸激酶; Toll 样受体4; 胰岛素样生长因子Ⅰ;Wortmannin; 肿瘤坏死因子 α; 白细胞介素 6Effect of Agonist and Inhibitor of PI3K/AKT on Inflammatory Response in Macrophages WANG Jing 1 ,XUPing 1 ,YANG Zhiwen 2 ,XU Kai 1 ,LAI Yuexing 1 .1 ...
inhibitor LY294002 to the mature medium can inhibit oocyte maturation, and reduce the number of blastocyst cells of parthenogenetic activation. KEYWORDS: porcine oocytes; porcine cumulus cells; PI3K/Akt signaling pathway; in vitro maturation VIII 目录 摘要... I Abstract ......
G-H: CFTR inhibitor172 可以抑制CFTR的离子通道作用,但同时增强了PTEN的磷酸化和去磷酸化作用; I-J: DMSO/PAK处理和DMSO/PAK+Staph/K. pneu(金黄色葡萄球菌/肺炎杆菌)处理后的细胞因子变化; 参考文献: [1] RIQUELME S A, HOPKINS B D, WOLFE A L, 等. Cystic Fibrosis Transmembrane Conductance Regulator...
与对照组比较,MIRI组心肌细胞中PTEN表达降低,PI3K、AKT及miR26a5p表达升高;与MIRI组比较,MIRI+miR26a5p mimic组心肌细胞中PTEN表达降低,PI3K、AKT及miR26a5p表达均升高,细胞活性降低;而MIRI+miR26a5p inhibitor组心肌细胞中PTEN表达升高,PI3K、AKT及miR26a5p表达均降低,细胞活性升高。
econazole was a new type of PI3K inhibitor, which inhibited the PI3K/AKT signaling pathway and reversed the resistance of breast cancer cells to doxorubicin137. Some studies showed that phenybutyl isoselenocyanate (ISC-4) treatment significantly inhibited PI3K/AKT activation in a dose-dependent manne...
KU-55933 (ATM Kinase Inhibitor) ≥98% 587871-26-9 5mg,25mg,100mg 无细胞 ATM 12.9 nM 2.2 nM K127121 KU-60019 ≥98% 925701-49-1 5mg,25mg,100mg 无细胞 ATM 6.3 nM V125220 VE-821 ≥98% 1232410-49-9 5mg,25mg,100mg 无细胞 ATR 26 nM 13 nM W100984 Wortmannin 98% 19545-26-7 ...