这表明肿瘤细胞中CDK4/6底物的表达/激活状态，以及肿瘤上皮细胞及其周围基质/免疫细胞中独立于基因组的PI3K/AKT/mTOR信号通路的激活，可能预测HR+/HER2-晚期乳腺癌患者对CDK4/6抑制剂联合ET的反应，有助于为这类患者制定更为个性化的治疗方案。参考文献：[1]NCCN Guidelines Breast Cancer Version 3. 2024. June ...
这表明肿瘤细胞中CDK4/6底物的表达/激活状态,以及肿瘤上皮细胞及其周围基质/免疫细胞中独立于基因组的PI3K/AKT/mTOR信号通路的激活,可能预测HR+/HER2-晚期乳腺癌患者对CDK4/6抑制剂联合ET的反应,有助于为这类患者制定更为个性化的治疗方案。 参考文献: [1]NCCN Guidelines Breast Cancer Version 3. 2024. June ...
PI3K/Akt/mTOR inhibitors in breast cancer PI3K / Akt / mTOR抑制剂在乳腺癌中的作用 ★ 1.Abstract 概述 ◆ Activation of the phosphoinositide【磷酸肌醇】 3 kinase (PI3K)/Akt/mammalian 【 [mæˈmeɪliən] 】...
这表明肿瘤细胞中CDK4/6底物的表达/激活状态,以及肿瘤上皮细胞及其周围基质/免疫细胞中独立于基因组的PI3K/AKT/mTOR信号通路的激活,可能预测HR+/HER2-晚期乳腺癌患者对CDK4/6抑制剂联合ET的反应,有助于为这类患者制定更为个性化的...
Activation of the phosphoinositide 3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is common in breast cancer. hTere is preclinical data to support inhibition of the pathway, and phase I to III trials involving inhibitors of the pathway have been or are being conducted in soli...
The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway is prevalently over-activated in human cancers and contributes to breast cancer (BC) growth, survival, proliferation, and angiogenesis, which could be an interesting therapeutic target...
2024年11月,Cancer Treatment Reviews在线发表了一篇名为“PI3K/AKT/mTOR inhibitors for hormone receptor-positive advanced breast cancer”的综述,总结了PI3K/AKT/mTOR抑制剂在HR+晚期乳腺癌的最新进展,并进一步讨论了这些抑制剂在临床实践中使用的诊断测试和其他考虑因素[6]。本文整理PI3K/AKT/mTOR抑制剂的作用机制...
PI3K/AKT/mTOR inhibitorsPhosphoinositide 3‐kinase(PI3K)/protein kinase B(PKB or AKT)/mammalian target of rapamycin(mTOR)signaling pathway(PAM pathway)plays an important role in the development of breast cancer and are closely associated with the resistance to endocrine therapy in advanced breast ...
5. Xiao W, Zhang G, Chen B, Chen X, Wen L, Lai J, Li X, Li M, Liu H, Liu J, Han-Zhang H, Lizaso A, Liao N. Mutational Landscape of PI3K-AKT-mTOR Pathway in Breast Cancer: Implications for Targeted Therapeutics. J Cancer. 2021 May 27;12(14):4408-4417. ...
磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(AKT)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路(PAM信号通路)在乳腺癌发生发展中发挥重要作用,与晚期乳腺癌内分泌治疗耐药密切相关,以PAM信号通路中的关键分子为靶点的抗癌治疗成为了近几年的研究热点。靶...