One of the main causes of low T3 uptake is a high amount of TBG in the blood. Why is this? Remember that T3 uptake measures the percent of TBG bound to thyroid hormones. If there is an excess amount of TBG, there will be more available to bind, which ultimately decreases the percent...
In the patients remaining euthyroid while taking amiodarone or after its withdrawal, but still under its influence as shown by the iodine overload, a 'low-T3 syndrome' is observed, this state being characterized by a high total T4, a low free T4, a normal T3 resin uptake, a low total ...
In the present study, we observed low striatal MCT8 levels in the THRSP OE mice, confirming that the reduction of striatal T3 is a consequence of low MCT8, impairs brain TH uptake54. Also, functional deletion of MCT8 induces hyperthyroxinemia and upregulates Thrsp (Spot14) mRNA levels ...
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The cytotoxic IPP compound, MOMIPP, causes early disruptions of glucose uptake and glycolytic metabolism. Coincident with these metabolic changes, MOMIPP selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL[2]. 体内活性 MOMIPP (80 mg/...
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Therefore, if thyrotoxicosis is clinically suspect, and T4 and FTI are normal, the test "T3 -RIA" is recommended (this is not the same test as "T3 uptake," which has nothing to do with the amount of T3 in the patient's serum). T4 is decreased in hypothyroidism and in euthyroid ...
SUMMARYA 16-year-old boy with chronic lymphocytic thyroiditis was noted to have a low free thyroxine (T4) level, low triiodothyronine resin uptake (T3U), and high serum thyrotropin (TSH) values. Unexpectedly, markedly elevated T3 radioimmunoassay (RIA) and T4 (RIA) values, using a double ant...
Currently, there is no consensus on the necessity of repeated radioiodine therapy (RAI) in patients who show iodine uptake in the thyroid bed on a diagnost... DJ Lim,HO Joo,MH Kim,... - 《Korean Journal of Internal Medicine》 被引量: 23发表: 2010年 加载更多来源...
OAT1 and 3, in conjunction with other uptake (e.g. OAT4, URAT1) and efflux (e.g. MRPs) transporters, belong to a suite of renal transporters whose function is to maintain circulating levels of endogenous anionic substances (e.g. uric acid) which might otherwise accumulate in the body....