But T3 uptake % is not very useful by itself. The T3 uptake test must be performed alongside a total T4 test in order to calculate free T4, also called the free T4 index. A high free T4 index may indicate hyperthyroidism while low levels may point to hypothyroidism [2]. The T3 uptake...
OAT1 and 3 are multispecific exchangers or antiporters that transport predominantly anionic substrates against a concentration gradient from the blood into proximal tubule cells for subsequent elimination into the urine. Uptake of substrates is dependent on the outwardly-directed concentration gradient of di...
In the present study, we observed low striatal MCT8 levels in the THRSP OE mice, confirming that the reduction of striatal T3 is a consequence of low MCT8, impairs brain TH uptake54. Also, functional deletion of MCT8 induces hyperthyroxinemia and upregulates Thrsp (Spot14) mRNA levels ...
Currently, there is no consensus on the necessity of repeated radioiodine therapy (RAI) in patients who show iodine uptake in the thyroid bed on a diagnost... DJ Lim,HO Joo,MH Kim,... - 《Korean Journal of Internal Medicine》 被引量: 23发表: 2010年 加载更多来源...
Thyroid iodine uptake was normal, thus, primary hyper-thyroidism was excluded. Since the patient had normal TFTspreviously, RTHβand FDH were unlikely. The discrepancybetween TSH and T3of the patient led to a suspicion of thedetected interference.The TSH concentrations of the patient before ...
Molecular and functional characterization of a novel low-affinity cation transporter (LCT1)in higher plants[J]. Proc Natl Acad Sci USA, 1997, 94 (20): 11079-11084. [12]Clemens S, Antosiewicz DM, Ward JM, et al. The plant cDNA LCT1 mediates the uptake of calcium and cadmium in ...
including hospitalization in the critical care setting [21]. The underlying mechanisms include multiple and complex alterations (i.e., inhibition of iodide uptake and organification, suppression of thyroglobulin synthesis and reduction of thyroid hormone secretion, inhibition of hypothalamus-pituitary-thyroid...
Altogether, we show that ccRCCs hijack nutrient reabsorption mechanisms (e.g. SLC1A1) to drive oncogenic programs. SLC1A1 thus links epigenetic dysregulation to a HIF-independent metabolic program regulating nucleotide biosynthesis/uptake.Abhishek A. ChakrabortyCancer research...
HepG2 cells show a relatively low expression of OATP1B364 and do not express NTCP65, while these two proteins are considered as main AMA uptake transporters. Therefore, HepG2 cells present lower sensitivity to AMA cytotoxicity compared to other common laboratory cell lines or primary hepatocytes...
OAT3 is expressed speci?cally in renal proximal tubule cells, where it facilitates the uptake of a broad array of endogenous and exogenous anions from the blood, across the tubular basolateral membrane, into the tubular cells (15, 23–25, 28). The cellular uptake of organic anions is ...