In the present study, we observed low striatal MCT8 levels in the THRSP OE mice, confirming that the reduction of striatal T3 is a consequence of low MCT8, impairs brain TH uptake54. Also, functional deletion of MCT8 induces hyperthyroxinemia and upregulates Thrsp (Spot14) mRNA levels ...
One of the main causes of low T3 uptake is a high amount of TBG in the blood. Why is this? Remember that T3 uptake measures the percent of TBG bound to thyroid hormones. If there is an excess amount of TBG, there will be more available to bind, which ultimately decreases the percent...
In Low T3 Syndrome, the concentration of thyroid binding proteins decreases as a consequence of the “acute phase response” (a.k.a. inflammation). For example, TBG levels decrease by as much as 60 percent in the 12 hours following bypass surgery.(6) In rodents, inflammation leads to a s...
HepG2 cells show a relatively low expression of OATP1B364 and do not express NTCP65, while these two proteins are considered as main AMA uptake transporters. Therefore, HepG2 cells present lower sensitivity to AMA cytotoxicity compared to other common laboratory cell lines or primary hepatocytes...
Molecular and functional characterization of a novel low-affinity cation transporter (LCT1)in higher plants[J]. Proc Natl Acad Sci USA, 1997, 94 (20): 11079-11084. [12]Clemens S, Antosiewicz DM, Ward JM, et al. The plant cDNA LCT1 mediates the uptake of calcium and cadmium in ...
Eukaryotic cells adjust their intracellular protein complement as a mechanism to adapt to changing environmental signals. In Saccharomyces cerevisiae the hexose transporters Hxt3 and Hxt7 are expressed and function on the plasma membrane in high and low
DCs are critical “decision-making” cells that must integrate signals from several pathways and receptors, including those arising from engagement of uptake and pattern recognition receptors, pro-inflammatory and anti-inflammatory cytokines, chemokines and hormones to determine the type and magnitude of ...
14. Narumi, K., et al., Mutual role of ecto-5'-nucleotidase/CD73 and concentrative nucleoside transporter 3 in the intestinal uptake of dAMP. PLoS One, 2019. 14(10): p. e0223892. 15. Pastor-Anglada, M. and S. Perez-Torras, Who Is Who in Adenosine Transport. Front Pharmacol, 2018...
Thus, root-specific CKX overexpression enhanced root system development and consequently increased drought tolerance, nutrient uptake and leaf nutrient enrichment in Arabidopsis [43,46]. Consequently, it is still difficult to estimate the precise nature of CK effects due to the complexity of ...
Among endocytic mechanisms, macropinocytosis has been described as a mean of extracellular nutrient uptake. Several pathogens are known to induce this process during their entry into host cells allowing the passive entry of bacteria27. To further investigate the impact of the macropinocytosis in HeLa ...