But T3 uptake % is not very useful by itself. The T3 uptake test must be performed alongside a total T4 test in order to calculate free T4, also called the free T4 index. A high free T4 index may indicate hyperthyroidism while low levels may point to hypothyroidism [2]. The T3 uptake...
resin T3 uptakeSerum levels of T 4 , T 3 rT 3 and resin T 3 uptake were followed for 5 days in 40 patients with acute myocardial infarction (AMI) allocated to early treatment either with alprenolol or placebo. There was a significant fall in T 3 (P<0.05) and an increase in rT 3...
In the present study, we observed low striatal MCT8 levels in the THRSP OE mice, confirming that the reduction of striatal T3 is a consequence of low MCT8, impairs brain TH uptake54. Also, functional deletion of MCT8 induces hyperthyroxinemia and upregulates Thrsp (Spot14) mRNA levels ...
OAT1 and 3 are predominantly renal anion-exchanging antiporters responsible for the uptake of substrates from the blood into renal proximal tubular cells. OAT1 and 3 are among the several important drug transporters in kidney proximal tubules that maintain systemic levels of endogenous substrates (e....
Thyroid iodine uptake was normal, thus, primary hyper-thyroidism was excluded. Since the patient had normal TFTspreviously, RTHβand FDH were unlikely. The discrepancybetween TSH and T3of the patient led to a suspicion of thedetected interference.The TSH concentrations of the patient before ...
Molecular and functional characterization of a novel low-affinity cation transporter (LCT1)in higher plants[J]. Proc Natl Acad Sci USA, 1997, 94 (20): 11079-11084. [12]Clemens S, Antosiewicz DM, Ward JM, et al. The plant cDNA LCT1 mediates the uptake of calcium and cadmium in ...
including hospitalization in the critical care setting [21]. The underlying mechanisms include multiple and complex alterations (i.e., inhibition of iodide uptake and organification, suppression of thyroglobulin synthesis and reduction of thyroid hormone secretion, inhibition of hypothalamus-pituitary-thyroid...
HepG2 cells show a relatively low expression of OATP1B364 and do not express NTCP65, while these two proteins are considered as main AMA uptake transporters. Therefore, HepG2 cells present lower sensitivity to AMA cytotoxicity compared to other common laboratory cell lines or primary hepatocytes...
It is highly expressed in the kidney, with mRNA expression greater than eightfold higher than OAT1, the next most abundant SLC22 transcript in the kidney (16, 21). OAT3 is expressed speci?cally in renal proximal tubule cells, where it facilitates the uptake of a broad array of endogenous ...
Among endocytic mechanisms, macropinocytosis has been described as a mean of extracellular nutrient uptake. Several pathogens are known to induce this process during their entry into host cells allowing the passive entry of bacteria27. To further investigate the impact of the macropinocytosis in HeLa ...