Definition The TCL 1 gene is involved in the generation and/or manifestation of the T-Prolymphocytic leukemia (T-PLL). Characteristics Clinical characteristics of the T-PLL The T-PLL is a disease that represents 20% of prolymphocytic leukemias. It occurs at an advanced age of 70 to 80 ...
T-幼淋细胞白血病(prolymphocyticleukemia, T-PLL)是一种临床非常罕见、且恶性程度极高的成熟T淋巴细胞肿瘤,年发病率仅约为0.6/100万[1]。肺癌是我国发病率和死亡率均较高的恶性肿瘤,其中肺腺癌几乎占全部肺癌的50%,且总生存率较低[2]。那么当罕见T-PLL与肺腺癌相遇时,将会带来怎样的挑战? 案例经过 患者,男...
T-幼淋细胞白血病(prolymphocyticleukemia, T-PLL)是一种临床非常罕见、且恶性程度极高的成熟T淋巴细胞肿瘤,年发病率仅约为0.6/100万[1]。肺癌是我国发病率和死亡率均较高的恶性肿瘤,其中肺腺癌几乎占全部肺癌的50%,且总生存率较低[2]。那么当罕...
确诊T-PLL要求在外周血或骨髓中发现T幼淋巴性细胞增殖,这些T细胞形态上存在3种变异[1,2,14,18-20]:最常见(75%)的是T-PLL细胞中等大小,核质比高,染色质集缩程度中等,可见单个核仁,胞浆略呈嗜碱性,不含颗粒,典型表现为胞质突起(小泡);20%的T-PL...
T-cell prolymphocytic leukemia (T-PLL) is a chemotherapy-resistant malignancy with a median survival of 7.5 months. Preliminary results indicated a high remission induction rate with the human CD52 antibody, CAMPATH-1H. This study reports results in 39 patients with T-PLL treated with CAMPATH-1H...
Adult T-cell leukemia/lymphoma CCR4: C-C chemokine receptor 4 ALCL: Anaplastic large cell lymphoma PD-L1: Programmed cell death ligand I OS: Overall survival Tregs: Regulatory T cells MDR: Multidrug resistance ABC: ATP-binding cassette
Adult T-cell leukemia/lymphoma, an aggressive T-cell neoplasm, is causally linked to human T-cell lymphotropic virus type 1 and based on this association has a distinct geographic distribution. In our United States-based practice, whose population is enr
p pT-cell prolymphocytic leukemia (T-PLL) is a rare form of leukemia composed of mature T-cells that usually presents in older people with a median age of 65. Most cases of T-PLL will harbor chromosomal abnormalities involving 14q11.2 (TCR alpha/delta), 14q32 (TCL1) or Xq28 (MTCP-...
【摘要】幼淋巴细胞白血病(prolymphocytic leukemia,PLL)是一种罕见但恶性程度极高的成熟淋巴肿瘤,其中T-细胞幼淋巴细胞白血病(T-cell prolymphocytic leukemia,T-PLL)这种亚型被认为难以治愈,临床治疗目的主要是提高治疗有效率和延长缓解期.随着对白血病发生发展机制研究的不断深入,目前T-PLL的治疗手段取得了较大的进步...
It has been reported that since the mid-1970 s, the 5-year relative survival rate of leukemia has increased from 50% to 87% (Howlader et al., 2015). In a study examining the effects of crocin on human promyelocytic leukemia cells, HL-60 cells, Sun et al. showed that crocin had ...