The prognosis of adult T-cell leukemia/lymphoma (ATL) with primary central nervous system (CNS) involvement has been unclear since the advent of new therapies. Recently, we have shown that flow cytometric CD7/CADM1 analysis of CD4+cells (HAS-Flow) is useful to detect ATL cells that are ...
成人T细胞白血病/淋巴瘤(adult T-cell leukemia/lymphoma, ATL)是一种高度侵袭性的T细胞恶性肿瘤,常伴有数十年无症状的慢性人类T淋巴细胞病毒1型(humanT-lymphotropic virus type 1, HTLV-1)感染,常发生于在儿童时期通过母乳喂养获得HTLV-1的携带者。HTLV-1在世...
Adult T-cell leukemia-lymphoma (ATL) is a distinct malignancy of CD4+/CD25+/CCR4+/FoxP3+ or- Treg/TH2 cells etiologically associated with human T-cell lymphotropic virus type I (HTLV-1). However, expression of the virus including Tax oncoprotein appears just after in vitro culture, ...
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive peripheral T-cell lymphoma caused by the human T lymphotropic virus type-1. The skin is affected in approximately half of ATLL patients, and skin lesions may be the first manifestation of the d...
Here we demonstrate that T cells expressing TCRs specific for peptides from the intracellular lymphoid-specific enzyme terminal deoxynucleotidyl transferase (TdT), presented in the context of HLA-A*02:01, specifically eliminate primary acute lymphoblastic leukemia (ALL) cells of T- and B-cell ...
Clinically, it is highly invasive and patients have a poor long-term prognosis. ETP-ALL originates from early thymic progenitors (ETP), and its gene mutation profile is different from typical T cell acute lymphoblastic leukemia (T-ALL). Such patients have poor response to conventional first-...
(T-ALL)accounts for 15% of pediatric and 25% of adult cases of acute lymphoblastic leukemia (ALL). Even though allogeneic hematopoietic stem cell transplantation (allo-HSCT) may be curative for T-ALL patients, disease rel...
of >6000 U/mL, could explain the poor prognosis in indolent ATL patients. The level of sIL-2R might be an indicator of the initiation of therapy for indolent ATL. Keywords: adult T-cell leukemia/lymphoma;smoldering-type;chronic-type;iATL-PI ...
cell leukemia 1 (TCL1) overexpression andATMloss, genetic alterations that are incorporated into the TPLL-ISG diagnostic criteria. The cooperativity betweenTCL1family members andATMis seemingly unique to T-PLL across the spectrum of T-cell neoplasms. The role of the T-cell receptor, its ...
Cancers derived from the malignant transformation of gamma–delta (γδ) T cells carry very poor prognosis. The major pathologies recognised are γδ T acute lymphoblastic leukaemia (γδ T-ALL), and two lymphoma subtypes: hepatosplenic T cell lymphoma (HSTL) and primary cutaneous γδ T cell...