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ARTICLE https://doi.org/10.1038/s41467-021-25101-9 OPEN Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia- lymphoma Makoto Yamagishi1,9, Miyuki Kubokawa1,9, Yuta Kuze2, Ayako Suzuki 3, Akari Yokomizo1, Seiichiro Kobayashi...
many of which are screened for in routine diagnostics. The only curative therapeutic option for many patients with AML today is allogeneic hematopoietic stem cell transplantation (allo-HSCT). Allo-HSCT remains, however, associated with high relapse rates as well as transplant...
In this review, we summarize the application of CRISPR–Cas9 on T cell activation, differentiation, and function. First, we describe the CRISPR–Cas9 application on different T cells. We then discuss its application in the adoptive T cells therapies in preclinical and clinical research. Finally, ...
“CTCL is an incurable disease that severely impacts a patient’s quality of life and has a poor prognosis in advanced stages. The systemic therapies currently approved for treatment rarely provide reliable and durable responses, and to-date, no investigational systemic therapies have shown outcomes ...
with a particular focus on blood cancers. It is worth noting that targeted CD19-CAR-T cell therapy has demonstrated efficacy in the treatment of aggressive and treatment-resistant acute leukemia [1]. As a result of the positive outcomes observed in clinical trials (Table1), numerous cell produ...
(TME) limit their use of it. Target selection is the most critical aspect in determining the prognosis of patients receiving this treatment. This review provides a comprehensive summary of all therapeutic targets used in the clinic or shown promising potential. We summarize CAR-T cell therapies’...
In recent decades, the advent of immune-based therapies, most notably Chimeric antigen receptor (CAR)-T cell therapy has revolutionized cancer treatment. The promising results of numerous studies indicate that CAR-T cell therapy has had a remarkable abil
stem cell transplant: longitudinal patient reported adverse events, cognition and quality of life [abstract]. Blood 134 (Suppl. 1), 794 (2019). Google Scholar Costello, C. L. et al. Phase 2 study of the response and safety of P-BCMA-101 CAR-T cells in patients with relapsed/...
and prognostic indicators founded on T cell marker genes, thereby shedding light on the significance of T cells in LUAD prognosis and precision treatment. The cellular phenotypes were identified by scrutinizing the single-cell data obtained from the GEO repository. Subsequently, T cell marker genes ...