[8]Ferrando A A, Neuberg D S, Staunton J, et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia[J]. Cancer Cell, 2002,1(1):75-87. [9]Graux C, Cools J, Michaux L, et...
8.Wang Y, Wei X, Yan D, et al. Sustained remission and decreased severity of CAR T ‐ cell related adverse events: a pivotal study report of CNCT19 (ianticabtagene autoleucel) treatment in adult patients w...
Adult T-cell leukemia/lymphoma (ATL) is an aggressive peripheral T cell lymphoma associated with human T cell lymphotropic virus Type-1 infection (HTLV-1). From: Pharmacology & Therapeutics, 2022 About this pageAdd to MendeleySet alert
[7]Chiesa R, Georgiadis C, Syed F, et al. Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia. N Engl J Med. 2023 Sep 7;389(10):899-910. doi: 10.1056/NEJMoa2300709. Epub 2023 Jun 14. PMID: 37314354. [8]Müller F, Boeltz S, Knitza J, et al. CD19-...
T- and B-cell subtypes of prolymphocytic leukemia (PLL) are rare, aggressive lymphoid malignancies with characteristic morphologic, immunophenotypic, cytogenetic, and molecular features. Recent studies have highlighted the role of specific oncogenes, such as TCL-1, MTCP-1, and ATM in the case of...
frequency of guanine targets substituted by adenine; HBV, hepatitis B virus; HTLV, human T-cell leukemia virus; MLV, mouse leukemia virus; Nsf, none so far; PBMC, peripheral blood mononuclear cells; SIV, simian immunodeficiency virus; SNV, spleen necrosis virus; SRV, simian retrovirus; Vif, ...
All replicates are biological Full size image Additionally, after CAR-T production by electroporation, the effector function of expanded T cells was evaluated. We observed that 19BBz MitoTpos cells showed an increasing trend in cytotoxic activity against Nalm-6 B cell leukemia after 96 h of co-...
2.Zhang X, Yang J, Li J, et al. Analysis of 60 patients with relapsed or refractory T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma treated with CD7-targeted chimeric antigen receptor-T cell therapy. Am J Hematol. 2023. ...
Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia. N Engl J Med. 2023 Sep 7;389(10):899-910. doi: 10.1056/NEJMoa2300709. Epub 2023 Jun 14. PMID: 37314354. [8]Müller F, Boeltz S, Knitza J, et al. CD19-targeted CAR T cells in refractory antisynthetase...
Affinity-optimized T cell receptors can enhance the potency of adoptive T cell therapy. Afamitresgene autoleucel (afami-cel) is a human leukocyte antigen-restricted autologous T cell therapy targeting melanoma-associated antigen A4 (MAGE-A4), a cancer/te