T cell acute lymphoblastic leukemia (T-ALL) is difficult to treat when it relapses after therapy or is chemoresistant; the prognosis of patients with relapsed or refractory T-ALL is generally poor. We report a case series of 17 such patients who received autologous chimeric antigen receptor (C...
Adult T-cell leukemia/lymphoma (ATL) is an aggressive peripheral T cell lymphoma associated with human T cell lymphotropic virus Type-1 infection (HTLV-1). From: Pharmacology & Therapeutics, 2022 About this pageAdd to MendeleySet alert
T-cell leukemia is relatively rare malignancy of thymocytes. There are around 20 entities and variants of this disease. Each of them has different characteristics, including pathogenesis, epidemiology, diagnosis, therapeutic approaches, and prognosis. Although T-cell leukemia is relatively rare malignancy...
peptides from the intracellular lymphoid-specific enzyme terminal deoxynucleotidyl transferase (TdT), presented in the context of HLA-A*02:01, specifically eliminate primary acute lymphoblastic leukemia (ALL) cells of T- and B-cell origin in vitro and in three mouse models of disseminated B-ALL....
(T-ALL)accounts for 15% of pediatric and 25% of adult cases of acute lymphoblastic leukemia (ALL). Even though allogeneic hematopoietic stem cell transplantation (allo-HSCT) may be curative for T-ALL patients, disease rel...
《Mutations and Delections of the TP53 Gen Predict Non response to Treatment and Poor Outcome in First Relapse of Childhood Acute Lymphoblastic Leukemia 》和《TP53 Germline Variations Influence the Predisposition and Prognosis of ...
prognosis and have facilitated risk stratification of patients.1,6Optimised risk stratification, coupled with improved chemotherapy regimens and haematopoietic stem cell transplantation (SCT), has resulted in improved rates of survival, such that 80% of paediatric and 50% of adult T-ALL patients now ...
It has been nearly half a century since angioimmunoblastic T-cell lymphoma (AITL) was characterized in the early 1970’s. Our understanding of the disease has dramatically changed due to multiple discoveries and insights. One of the key features of AITL
Int J Dermatol Venereol, 2022,5(1): 40-44 Abstract Adult T-cell leukemia/lymphoma (ATLL) is an aggressive peripheral T-cell lymphoma caused by the human T lymphotropic virus type-1. The skin is affected in approximately half of ATLL patients, an...
Acute myeloid leukemia (AML) is a disease with high incidence of relapse that is originated and maintained from leukemia stem cells (LSCs). Hematopoietic stem cells can be distinguished from LSCs by an array of cell surface antigens such as CD123, thus a candidate to eliminate LSCs using a ...