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这其中一个重要的研究方向是细菌用核酸开关(T-box riboswitch)感受tRNA氨酰化(aminoacylation)程度来控制氨基酸饥饿反应的过程。这种通过noncoding RNA switch直接进行的基因调控的方式由于其简洁而高效而在细菌中广泛存在, 是细菌针对环境和自身体内营养...
the last rnant the last son of krypt the last syllable of the last time joey we the last trading date the last trump the tr the last two question the last waltz should the lastlong eternal the latest date of ta the latest view the latter include the latter part of on the latter part...
作为RNA世界里最古老的几种RNA,tRNA的方方面面都有许多故事可讲,从核酸结构折叠,化学修饰,与核糖体的作用,病毒复制以及降解片段的表观遗传学功能等不一而足。 这其中一个重要的研究方向是细菌用核酸开关(T-box riboswitch)感受tRNA氨酰化(aminoacylation)程度来控制氨基酸饥饿反应的过程。这种通过noncoding RNA switc...
Mansfield et al., "Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing" 7 Gene Therapy 1885-1895 (2000) Verma et al., "Gene Therapy: Twenty-First Century Medicine" 74 Annual Review of Biochemistry 711-738 (2005) Claims: What is claimed is: 1. A method of regulating data ...
为了研究TIR-APAZ和Ago蛋白之间的相互作用模式,作者首先从Maribacter polysiphoniae(以下简称TIR / Ago复合物,也称为SPARTA)中共纯化二元复合物,并在存在guide RNA(gRNA)的情况下测定其冷冻电镜结构。通过体外NAD降解实验证明,apo TIR/Ago和RNP复合物中的TIR结构域在催化上无活性,但tDNA结合可以有效地激活NADase活性...
末端携带C的RNA再形成一个更小的Loop环,形成更加稳定的3'末端碱基配对,从而启动RNA的自我延伸。 III类型序列II类序列在启动子驱动的反应产物和自我延伸反应产物中占比都是4%,同样,3'末端延伸序列的长度存在异质性。 总的来说,在IVT反应中,Run ...
Influence of non-enzymatic template-directed RNA recombination processes on polynucleotides lengths in Monte Carlo simulation model of the RNA World UV—irradiated single-stranded synthetic homopolymers were used to characterise an antiserum made against UV-irradiated DNA. Using induction data obtained .....
RNA -CAMBRIDGE-On the occurrence of the T-loop RNA folding motif in large RNA molecules - Krasilnikov, Mondragon - 2003 () Citation Context ... 0 to the conserved adenosine (16). It was later discovered that the T-loop motif could also exist in single strand non-ordered regions without...
Martin推测,这种类型的序列可能是通过C图所示的发卡结构模型形成的,这种发卡结构中存在3个互补配对的碱基(GU是RNA结构中最为稳定的配对碱基),形成一个相对较小的Loop环,从而启动RNA的自我转录。但是,RNA自我延伸停止的位置是异质性的,这就造成I类序列内部又划分为各种不同类型的序列。