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细胞毒性T细胞(Cytotoxic T Cells,简称Tc细胞)是适应性免疫系统的关键组成部分,主要通过直接杀伤受感染或癌变的细胞来维持
Cytotoxic T cells are CD8-postive T cells that are specialized for the direct killing of cells that are infected (particularly with viruses), cancerous or damaged in other ways. They express the glycoprotein CD8, as well as T cell receptors that recognize antigenic peptides presented by MHC cl...
细胞毒T细胞(CTL,Cytotoxic T cell),其主要功能是分泌穿孔素和颗粒酶,杀死被感染细胞和突变细胞。细胞毒性T细胞的主要表面标志是CD8,也称为杀手 T 细胞。 γδT细胞 γδ T细胞,常在组织上皮细胞表面富集,根据免疫微环境既可促炎也可抗炎,同时具有先天免疫和适应...
细胞毒性T细胞(Cytotoxic T cells,Tc),具有杀伤靶细胞的功能;迟发性变态反应T细胞(Delayed type hypersensitivityT cells,Td),有参与Ⅳ型变态反应的作用;放大T细胞(Ta),可作用于Th和Ts,有扩大免疫效果的作用;原始的或天然T细胞(Virgin or Natural T cells),他们和抗原接触后分化成效应T细胞和记忆T细胞;记忆T细胞(...
2021年6月24日,细胞杂志上发表了名为“CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment”的文献[2],文章发现趋化因子CXCR6能够支持和调节CTLs在肿瘤微环境(TME)中的生存和抗肿瘤活性。 CXCR6...
Cytotoxic T lymphocytes (CTLs) represent one of several types of cells of the immune system that have the capacity to directly kill other cells. They play a major role in host defense against viral infection, as well as infection by other intracellular pathogens that replicate in the cytoplasm...
Cytotoxic T lymphocytes (CTLs) often called CD8+ T cells, are a critical component of the adaptive immune system and play an important role in immune defense against intracellular pathogens such as viruses and bacteria and against tumors [1]. Like helper CD4+ T ...
Activated CTLs secrete cytokines and can kill target cells expressing the same MHC/antigen complex. Since, with a few exceptions, all nucleated cells express MHC class I, the role of CTL is to monitor all the cells of the body, ready to destroy any that express foreign antigen fragments in...