Improved understanding of CD8+T cell function during HIV infection is vital to designing an HIV cure. We have identified a subset of lymph node CD8+T cells that demonstrate simultaneous stem-like and effector properties and are strongly associated with viral control during SIV and HIV infection. ...
Furthermore, we demonstrate that neutralization of TGF-β restores expression of these genes in tumor-specific CD8+ T cells in vivo, leading to tumor clearance. These results suggest that TGF-β suppresses CD8+ T cell cytotoxicity in vivo through repression of a distinct program of cytotoxic ...
plural cytotoxic T cells also cytotoxic T lymphocytes : a T cell that usually bears CD8 molecular markers on its surface and that functions in cell-mediated immunity by destroying a cell (such as a virus-infected cell) having a specific antigenic molecule displayed on its surface Viruses use ...
MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness. 来自 Semantic Scholar 喜欢 0 阅读量: 96 作者:RM Zinkernagel,PC Doherty ...
Cytotoxic T-cellsdoi:10.1007/3-540-29832-0_467Cytotoxic T-cells, or cytolytic T-cells (CTLs), are effector cells of the immune system that carry the CD8 surface marker. These cells are able to recognize autologous cells expressing foreign......
Structure and Function of the Immune System Mona Sadeghalvad, ... Nima Rezaei, in Encyclopedia of Infection and Immunity, 2022 Cytotoxic T cells (CTLs) Cytotoxic T cells are an important subset of T cells that respond to intracellular infections such as viruses and malignant cells. These cells...
CD8+T cells (Fig.3f, g). In line with these results, more F-actin was observed in human CD8+T cells transfected withYAPsiRNA or treated with the inhibitor (Fig.3h, i). Owing to the lack of a DNA-binding domain, YAP acts as a transcription co-activator to exert its function by ...
Activated CTLs secrete cytokines and can kill target cells expressing the same MHC/antigen complex. Since, with a few exceptions, all nucleated cells express MHC class I, the role of CTL is to monitor all the cells of the body, ready to destroy any that express foreign antigen fragments in...
The response of peritoneal exudate lymphocytes to allogeneic tumor cells was used to determine whether the in vivo generation of cytotoxic T cells (CTL) involved the proliferation of precursor cells. Ten days post-injection, both cytotoxic activity and the formation of conjugates between lymphocytes an...
cells were completely reversed by transfection of these cells with a wild-type lck expression vector. These results indicate that p56lckexpression is not obligatory for IL-2-mediated T-cell growth stimulation; however, this PTK plays a central role in the generation T-cell-mediated cy...