细胞毒性T细胞(Cytotoxic T Cells,简称Tc细胞)是适应性免疫系统的关键组成部分,主要通过直接杀伤受感染或癌变的细胞来维持
Cytotoxic T CellsELSEVIERImmunology for Pharmacy
Cytotoxic T cells are CD8-postive T cells that are specialized for the direct killing of cells that are infected (particularly with viruses), cancerous or damaged in other ways. They express the glycoprotein CD8, as well as T cell receptors that recognize antigenic peptides presented by MHC cl...
Activated CTLs secrete cytokines and can kill target cells expressing the same MHC/antigen complex. Since, with a few exceptions, all nucleated cells express MHC class I, the role of CTL is to monitor all the cells of the body, ready to destroy any that express foreign antigen fragments in...
What are cytotoxic T cells? Cytotoxic T lymphocytes (CTLs) often called CD8+ T cells, are a critical component of the adaptive immune system and play an important role in immune defense against intracellular pathogens such as viruses and bacteria and against tumor...
The key players of adaptive cellular immune responses are T lymphocytes in general and, for the effector function, cytotoxic T lymphocytes (CTLs) in particular. T lymphocytes arise in the bone marrow and migrate to the thymus for maturation. During this process, T cells somatically rearrange ...
然而体内的细胞毒性T细胞则是癌细胞的克星,它在体内不断地巡逻找出并杀死癌细胞或者感染了危险病毒的细胞。当癌细胞遇到细胞毒T细胞或杀伤性T细胞时,便可杀死癌细胞。如图橙色的是细胞毒T细胞,蓝色的是癌细胞,最近英国剑桥大学的研究人员利用最先进的成像技术,真实记录了杀死癌细胞的过程。
Define Cytotoxic T-cells. Cytotoxic T-cells synonyms, Cytotoxic T-cells pronunciation, Cytotoxic T-cells translation, English dictionary definition of Cytotoxic T-cells. n. See killer cell. American Heritage® Dictionary of the English Language, Fifth
CD4+ T cells can either enhance or inhibit tumour immunity. Although regulatory T cells have long been known to impede antitumour responses1,2,3,4,5, other CD4+ T cells have recently been implicated in inhibiting this response6,7. Yet, the nature and function of the latter remain unclear...
The functions of, and interactions between, the innate and adaptive immune systems are vital for anticancer immunity. Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of