Cancer stem cellsChimeric antigen receptor T cellsCSC antigensFor decades cancer remained the center of attention in the scientific community as its survival rates are low. Researchers from all around the world wanted to know the core of the problem as to what initiates cancer in a patient and...
et al. Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells. Clin. Cancer Res. 19, 5636–5646 (2013). Article CAS PubMed Google Scholar Newick, K. et al. Augmentation of CAR T-cell trafficking and antitumor efficacy by blocking ...
T cells have the capacity to eradicate diseased cells, but tumours present considerable challenges that render T cells ineffectual. Cancer cells often make themselves almost 'invisible' to the immune system, and they sculpt a microenvironment that suppresses T cell activity, survival and migration. Ge...
Due to its defective constitutive production of inflammatory cytokines and other growth factors, a stroma is built at the site of inflammation similar to the temporary stroma built during wound healing. The cancer cells grow inside this stroma, forming a tumor that provides their vascular supply ...
T cells engineered to express chimeric antigen receptors (CARs) that are specific for tumour antigens have led to high complete response rates in patients with haematologic malignancies. Despite this early success, major challenges to the broad applicati
CTLs can mediate direct cytotoxic effects on target cells (e.g., infected or transformed cells), whereas helper CD4+ T cells mostly provide help for CTL function. Although the majority of effector T cells die after eradication of pathogens or cancer cells, a heterogeneous pool of memory T ...
Depressed monocyte polarization and clustering of dendritic cells in patients with head and neck cancer: In vitro restoration of this immunosuppression by ... The in vitro restoring effects of a thymic hormone preparation, TP-1, on defective monocyte and dendritic cell function in patients with ...
cancer therapy; immune checkpoints; immunotherapy; CAR-T cells Graphical Abstract1. Introduction Cancer is the second-largest reason for mortality after cardiac disease, with a world incidence and mortality of about 14.1 million and 8.2 million deaths per year, respectively [1]. This disease is ...
Tumor microenvironment of cancer stem cells: Perspectives on cancer stem cell targeting Genes & DiseasesJournal2024,Genes & Diseases QianqianGuo, ...WenzhouZhang T cells CytotoxicT lymphocytes(CTLs) are a subset of leukocytes that secrete various cytokines specifically for immune function. These cells...
In animal systems, complete and permanent eradication of tumours can be achieved by adoptive transfer of MHC-restricted T cells, combined with IL2. In cert... CJM Melief,WM Kast - 《Research in Immunology》 被引量: 78发表: 1991年 CAR T-cells for cancer therapy immunotherapyT-cellcancersingl...