[3]Luo T I,et al.Abstract CT069: Targeting EpCAM via CAR T-cells is an effective treatment for gastric cancer patients and subsequent toll-like receptor signaling activation in CD36+ monocyte underlies the resulting cyto...
Journal for ImmunoTherapy of Cancer,Cancer Letter,Frontiers in Immunology编委。长期从事分子和细胞免疫学研究,集中在 T 细胞、天然淋巴细胞发育、分化、异质性和功能中信号传导以及分子调节机制等方面。解析了人 T 细胞起源和胸腺发育的关键事件,人胚胎期天然淋巴...
In the current study, we sought to extend T cell therapy to the treatment of pancreatic cancer. However, a prerequisite step involved the identification of a target antigen which is present on the cell surface and is expressed or overexpressed on malignant cells, but has limited expression on ...
N. et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells. Blood 119, 2709–2720 (2012). Koury, J. et al. Immunotherapies: exploiting the immune system for cancer treatment. J...
19. Chen, J., et al., Preconditioning chemotherapy with cisplatin enhances the antitumor activity of cytokine-induced killer cells in a murine melanoma model. Cancer Biother Radiopharm, 2012. 27(3): p. 210-20. 20. Bergmann-Leitner, E.S. and S.I. Abrams, Treatment of human colon carcinom...
specific cancer. These engineered T cells, called chimeric antigen receptor, or CAR, T cells, have been recently used as treatment for cancer, said Philip S. Low, Purdue's Ralph C. Corley Distinguished Professor of Chemistry and director of the Purdue Center for Drug Discovery who led the ...
Cancer immunotherapy aims to promote the activity of cytotoxic T lymphocytes (CTLs) within a tumour, assist the priming of tumour-specific CTLs in lymphoid organs and establish efficient and durable antitumour immunity. During priming, help signals are relayed from CD4+ T cells to CD8+ T cells...
2022-11-07报道,近日,“CAR-T之父”、宾夕法尼亚大学的Carl June教授在Cell Research期刊发表了题为:Off-the-shelf CAR T cells to treat cancer 的文章,评述了北恒生物联合浙江大学黄河教授团队所做的一项通用型CAR-T细胞疗法治疗血液系统恶性肿瘤的1期临床试验成果。
海德堡大学医院神经外科的Dr Christel Herold-Mende及其团队评估了临床样本中TIL含量及其在pMGM和rMGM中的活化状态及其预后影响。该文章发表在Clinical Cancer Research上。 通过定量分析发现,t细胞浸润极为不均匀,范围为0.01 - 24.88%,其中中位T细胞浸润占总细胞数量的0.59%。尽管在原发性脑膜瘤中辅助T细胞(CD3+CD8-FOX...
And which tumor specific anti-tumor cells are mainly used for the treatment of HCC by CAR-T cell therapy? Dr. Ho: Well, that's a really good question. We do not know exactly how CAR-T cell treatment in liver cancer is re...