其次,TIL在体内被肿瘤抗原刺激后,通常主要由效应记忆T细胞(effector memory T cells, Tem)组成,其表面表达趋化因子受体,如CCR5和CXCR3。TIL与肿瘤特异性TCR一起,在转移到患者体内后,可以很容易地定位于表达抗原的组织,包括肿瘤。 最后,TIL治疗中很少报道靶向毒性,这可能是由于在T细胞免疫早期发展过程中,TIL的TCR选择...
Ping Y, Liu C, Zhang Y (2018) T-cell receptor-engineered T cells for cancer treatment: current status and future directions. Protein & cell 9: 254-266Ping Y, Liu C, Zhang Y. T-cell receptor- engineered T cells for cancer treatment: cur- rent status and future directions. Protein ...
1.Complete Regression of Metastatic Cervical Cancer After Treatment With Human Papillomavirus–Targeted Tumor-Infiltrating T Cells - PMC (nih.gov) 2.FDA grants accelerated approval to tisotumab vedotin-tftv for recurrent or metastatic cervical cancer | FDA...
[2]2024 AACR: Targeting EpCAM via CAR T-cells is an effective treatment for gastric cancer patients and subsequent toll-like receptor signaling activation in CD36+ monocyte underlies the resulting cytokine release syndrome [3]2024 AACR: Phase I first-in-human MUC1* targeted autologous CAR T ce...
[3]Luo T I,et al.Abstract CT069: Targeting EpCAM via CAR T-cells is an effective treatment for gastric cancer patients and subsequent toll-like receptor signaling activation in CD36+ monocyte underlies the resulting cyto...
1.Slaney, C. Y., Wang, P., Darcy,P. K. & Kershaw, M. H. CARs versus BiTEs: a comparison betweenT cell-redirection strategies for cancer treatment. Cancer Discov. 8,924–934 (2018) 2.Jennifer D Stone et al,A sensitivity scale for targeting...
cells, with terminal Tex cells dramatically decreased following treatment. This difference was possibly due to a variable degree of immunosuppression in different cancer types, or to the concurrent chemotherapy used in these patients with lung cancer. Future therapeutic strategies to enhance the ...
2. Li Yin, Gui-Lai Chen , Zhuo Xiang, etal. Current progress in chimeric antigen receptor-modified T cells for the treatment of metastatic breast cancer [J]. Biomed Pharmacother, 2023 Jun;162:114648. doi: 10.1016/j.biopha.2023.114648. ...
1.Engineered TCR-T CellI mmunotherapy in Anticancer Precision Medicine: Pros and Cons. Front Immunol. 2021;12: 658753. 2. Evolution of CD8+ T Cell Receptor(TCR) Engineered Therapies for the Treatment of Cancer. Cells. 2021 Sep;10(9): 2379....
[3]Botta GP,et al.Metastatic gastric cancer target lesion complete response with Claudin18.2-CAR T cells. J Immunother Cancer. 2024 Feb 5;12(2):e007927. https://pubmed.ncbi.nlm.nih.gov/38316518/ [4]https://on...