T cells have the capacity to eradicate diseased cells, but tumours present considerable challenges that render T cells ineffectual. Cancer cells often make themselves almost 'invisible' to the immune system, and they sculpt a microenvironment that suppresses T cell activity, survival and migration. Ge...
in the future, also solid cancers are to be treated using CAR T cells because solid cancers are more frequent compared with hematological malignancies. However, the demand for CAR T cells and related adoptive immunotherapies will likely exceed the current production capacity. To unleash the full po...
Redirected primary T cells harboring a chimeric receptor require costimulation for their antigen-specific activation. Blood 105, 3087–3093 (2005). Article CAS PubMed Google Scholar Brocker, T. Chimeric Fv-ζ or Fv-ε receptors are not sufficient to induce activation or cytokine production in ...
for the first-time, quantify protein production in T-cells. T cells are immune cells that surveil the body and can effectively target and kill cancer cells. However, when T cells are in the vicinity of a tumor, cancer
【ICI-mediated antitumor responses depend on the infiltration of T cells capable of recognizing and killing tumor cells.】ICI 对“冷肿瘤”无效【ICIs are not effective in "cold tumors"】,其特征是缺乏 T 细胞浸润。为了充分发挥免疫疗法的潜力并解...
Mantle cell lymphoma (MCL) is a subtype of Non-Hodgkin lymphoma (NHL) of mature B-cells characterized by translocation, which is typically due to excess expression of Cyclin D1. Although with the progress in our knowledge of the causes for MCL and available treatments for MCL, this cancer ...
Local and Regional Cancer Immunosurveillance: A Critical Role for Tissue-Resident Memory T (TRM) Cells The immune system can suppress cancer development and progression by engaging in a process termed ‘cancer immunosurveillance’ (Figure 1, Box 1). Although many innate and adaptive immune cells can...
Upon infection with influenza virus, production of cytokines and chemokines including CCL3, CCL4, and CCL5 from respiratory epithelium recruits γδ T cells at the site of infection in a CCR5 receptor-dependent fashion. Next, γδ T cells become activated in response to influenza virus infection...
IFN-γ production and cytotoxicity while maintaining the gene networks responsible for stem-like plasticity. Accordingly, adoptive transfer of tumor-specific T cells resulted in superior anti-tumor immunity in a humanized mouse model. In mice, a high-salt diet reduced the growth of experimental tu...
Cancer immunology and immunotherapy are driving forces of research and development in oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent progress highlights the importance of CD4+ T cells, corresponding to the long-known fac