T-cell costimulatory molecules: optimal targets for the treatment of allergic airway disease with monoclonal anti- bodies. J Allergy Clin Immunol 2005; 116: 906-909.Kroczek, R. & Hamelmann, E. T-cell costimulatory molecules: optimal targets for the treatment of allergic airway disease with ...
Thus, a major goal of novel immune-based therapies is the coordinate silencing of regulatory circuits and amplification of protective T cell function. 展开 关键词: Immunology Oncology Cancer immunotherapy targeting T cell costimulatory molecules UNIVERSITY OF PITTSBURGH Walter J. Storkus Pardee Angela D...
(t1/2) of 102.5 s for hB7.1, and aKDof 388 nM and t1/2 of 20.7 s for hB7.2, respectively. Generally, the costimulatory molecules B7.1/2 are expressed on the surface of antigen-presenting cells and interact with CD28/CTLA4 to regulate T-cell response, and the M2 protein is...
Isono T, Seto A (1995) Cloning and sequencing of the rabbit gene encoding T-cell costimulatory molecules. Immunogenetics 42: 217-220Isono, T., and Seto, A. 1995. Cloning and sequencing of the rabbit gene encoding T-cell costimulatory molecules. Immunogenetics 42 :217–220....
et al. T-cell signaling and costimulatory molecules in B-chronic lymphocytic leukemia (B-CLL): an increased abnormal expression by advancing stage. Leukemia 17, 2252–2254 (2003). https://doi.org/10.1038/sj.leu.2403100 Download citation Published24 October 2003 Issue Date01 November 2003 DOI...
They respond to specific antigens through interactions of specific antigen receptors presented by major histocompatibility complex molecules and a group of costimulatory molecules. Once activated, they can kill their target cells or produce cytokines that activate or suppress the growth, movement, or ...
During the past several years, the critical role of costimulatory molecules in regulating T cell responses has been demonstrated. Costimulatory molecule CD28 enhances whereas CTLA-4 downmodulates T cell responses. An understanding of the integration of the signals mediated by costimulatory molecules and ...
XY-E11250 【中文名称】人协同刺激分子受体(CMR)ELISA试剂盒品牌 【英文名称】Human costimulatory molecules recptor,CMR ELISA试剂盒多少钱 XY-E11251 【中文名称】人肽聚糖(PG)ELISA试剂盒品牌 【英文名称】Human peptidoglycan,PG ELISA试剂盒多少钱 XY-E11252 【中文名称】人脂阿拉伯甘露聚糖(LAM)ELISA试剂盒品...
Effector T cells (TEF) have been divided by the expression of CD127 and killer cell lectin-like receptor G1 (KLRG1) [6] (Fig.1). CD127hiTEFhighly express antiapoptotic molecules and give rise to memory cells that persist and exert long-term protective immunity. Thus, selective expression ...
In contrast, the T cells located in the dermis or hair follicle regions expressed both costimulatory molecules. The lack of CD80/86 on KCs and CD28 on T cells in situ in the epidermis supports our hypothesis that the interplay between CD58 and CD2 plays a crucial role in KC-mediated T ...