T cell co-stimulatory molecules: a co-conspirator in the pathogenesis of eosinophilic esophagitis? Dig Dis Sci. 2013;58(6):1497–506.T Cell Co-Stimulatory Molecules: A Co-conspirator in the Pathogenesis of Eosinophilic Esophagitis?[J] . Zili Zhang,Thomas J. Sferra,Yasemen Eroglu.Digestive ...
However, the interaction of T-cell with antigen on the antigen-presenting cell is not sufficient to elicit T-cell activation. The T-cell must receive a second signal from the antigen-presenting cell. These co-stimulatory signals are mediated by other proteins on the antigen-presenting cell ...
Summary The role of T-cell co-stimulatory molecules in murine models of allergic asthma. Allergen-specific T helper type 2 (Th2) cells play a pivotal role in the pathogenesis and progression of allergic asthma by orchestrating the inflammatory response. For optimal activation, T-cells require non...
Generate a more robust anti-tumor response with our selection of agonistic antibodies and small molecules for immune cell co-stimulatory molecules.
The central role of co-stimulatory and co-inhibitory receptors in T cell biology has been proven by the effective therapeutic targeting of some of these molecules. However, the molecular aspects of T cell co-stimulation and co-inhibition are far from bei
This shift involves the induction of a myriad of factors including effector cytokines, lineage-restricted transcription factors, and surface markers such as co-stimulatory molecules, immune checkpoint proteins, a...
Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40 Sugamura K, Ishii N, & Weinberg AD (2004) Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40. Nat Rev Immunol 4(6):420-431.Sugamura, K., N. Ishii, and A. D. Weinberg. 2004. Therapeutic ...
Signaling by the co-stimulatory molecules TCR engagement leads to activation of proximal and distal signaling pathways. However, productive T cell activation also involves the engagement of additional cell surface receptors, i.e., co-stimulatory molecules like CD28. This is required to avoid anergy,...
The tyrosine phosphatase CD45 is a major gatekeeper for restraining T cell activation. Its exclusion from the immunological synapse (IS) is crucial for T cell receptor (TCR) signal transduction. Here, we use expansion super-resolution microscopy to revea
T cells upregulate several molecules upon activation of their T-cell receptor (TCR). For example, CD28 mediates co-stimulatory signals in T cells following TCR stimulation. Five major CD4 Th cell subsets have been identified, namely Th1, Th2, Th17, Treg (T regulatory), and Tfh (follicular ...