Co-stimulation in T cell responses. Curr Opin Immunol 1997; 9: 396.Chambers CA, Allison JP. Co-stimulation in T cell responses. Curr Opin Immunol 1997; 9:396-404.Chambers, C.A., Allison, J.P. (1997) Co-stimulation in T-cell responses. Curr. Opin. Immunol. 9, 396-404....
Co‐stimulation of T cells results in distinct IL‐10 and TNF‐α cytokine profiles dependent on binding to ICAM‐1, ICAM ... van Kooyk Y ( 1999 ) Co-stimulation of T cells results in distinct IL-10 and TNF-alpha cytokine profiles dependent on binding to ICAM-1, ICAM-2 ... DA ...
Co-stimulatory and co-inhibitory receptors have a pivotal role in T cell biology, as they determine the functional outcome of T cell receptor (TCR) signalling. The classic definition of T cell co-stimulation continues to evolve through the identification of new co-stimulatory and co-inhibitory re...
By tracking the fate of tumor-specific T cells mobilized in lymph nodes by dual blockade of PD-1 and TIGIT, we show that both exhausted T cells and effector T cells can emerge from a common progenitor. Signaling by the co-stimulatory receptors CD28 and C
The interplay between keratinocytes and immune cells, especially T cells, plays an important role in the pathogenesis of chronic inflammatory skin diseases. During psoriasis, keratinocytes attract T cells by releasing chemokines, while skin-infiltrating self-reactive T cells secrete proinflammatory cytokines...
CD28 amplifies membrane-proximal signalling that is generated by TCR ligation. TCR stimulation generates the central scaffolding (that is, the adaptors linker for activated T cells (LAT) and SH2-domain-containing leukocyte protein of 76 kDa (SLP76) on which CD28-activated signalling elements might ...
The role of B7 co-stimulation in activation and differentiation ofCD4+and CD8+T cells Summary: The functional significance of B7 co-stimulation in T-cell activation was described first in the context of preventing the induction of anergy. Th... AJM Adam,AN Schweitzer,AH Sharpe - 《Immunologica...
Antigen-driven induction of CD11c on intestinal intraepithelial lymphocytes and CD8+ T cells in vivo. Intraepithelial lymphocytes (IEL) of the intestinal epithelium represent a phenotypically and functionally distinct subpopulation of peripheral T cells. In... J. W. and Huleatt,L Lefrançois - 《...
In vivo T cell co-stimulation TL1A constructs were evaluated for the ability to co-stimulate T cells to produce cytokine in an in vivo mouse model. Suboptimal dose of anti-mouse CD3 antibody (2 mg/mouse) (BioXCell, clone 145-2C11 F(ab)2 fragment; cat. # BE0001-1FAB) was injected...
Here we show that CAR-T cells targeting simultaneously two tumor-associated antigens and providing trans-acting CD28 and 4-1BB co-stimulation, while sharing the same CD3ζ-chain cause rapid antitumor effects in in vivo stress conditions, protection from tumor re-challenge and prevention of tumor...