Knockdown of IFI16 or inhibition of HIV reverse transcriptase rescues quiescent T cells from this form of cell death induced by abortive HIV infection. Thus, HIV coopts the host-cell innate response. Such killing of bystander T cells might account for much of the loss of CD4+ T cells ...
These findings further support the conclusion that HIV killing of abortively infected bystander CD4 T cells requires cell-to-cell transfer of virions. As bNAbs attract more interest as potential therapeutics, it will be important to consider the higher concentrations of these antibodies required to ...
在粘液瘤病毒介导的自亡期间,这种疗法靶向攻击的癌细胞附近的其他癌细胞也会在一种称为旁观者杀伤(bystander killing)的过程中被摧毁。 这种效果可以显著提高这种双重疗法对癌细胞的积极根除效果,即使是在出了名的难以治疗的实体瘤中,也是如此。 因此,这种联合使用粘液瘤病毒和免疫疗法的方法有可能将免疫系统无法检测到...
Killing bystander T cellsHIV infectionsCD4 antigenT cellsCELL deathAIDSVIRAL genomesINTERFERONSNo abstract available.doi:10.1038/ni.2840DempseyLaurie APubMedNature Immunology
[6]Ogitani Y, Hagihara K, Oitate M, et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107(7):1039-46. ...
Results: FAP‐CAR‐T cells exhibited target specificity against model cell lines and potent cytotoxicity against patient‐derived glioma neural stem cells, even when only a subpopulation expressed FAP, indicating a bystander killing mechanism. Using co‐culture assays, we confirmed FAP‐CAR‐T...
BiTE antibody constructs are single-chain bispecific antibodies with specificity for CD3 on the T cell and a selected surface antigen on a tumor cell. When... S Ross 被引量: 0发表: 2017年 Abstract LB-232: BiTE antibody constructs can mediate bystander tumor cell killing Recent clinical data ...
第一代ADC药物存在很多不足,以惠氏(后被辉瑞收购)和Celltech(后被优时比收购)的CD22靶向ADC药物——吉妥珠单抗(Mylotarg)为例,其采用酸敏感性连接子,容易受到体内酸环境影响而过早裂解,因而脱靶毒性较高;并且Mylotarg的均一性很差,其产品中50...
2024年4月12日,陆军军医大学叶丽林团队与合作者中国农业大学张国中团队、北京大学白凡团队及南京大学李颜团队在Nature Cancer杂志发表了题为An oncolytic virus delivering tumor-irrelevant bystander T cell epitopes induces anti-tumor immunity and potentiates cancer immunotherapy的研究论文,该研究系统地阐明了TBYS细胞的...
issue ofScience Immunologysolves this mystery, with a surprising revelation. In it a team led by La Jolla Institute for Allergy and Immunology (LJI) diabetes researcher Matthias von Herrath, M.D., reveals thatbystandercell accumulation antagonizes rather than abets cell-killing by specific CTLs, ...