stimulation14,15. Interestingly, the TCR-independent activation of CD4+T cells has primarily been observed in memory (CD44high) cells, while naïve (CD44low) cells exhibit lower reactivity13,14,15. Thus, it appears that cytokines and innate receptors, such as Toll-like receptors (TLRs), ca...
As bNAbs attract more interest as potential therapeutics, it will be important to consider the higher concentrations of these antibodies required to block theinflammatory death of bystander CD4 T cells.doi:10.1016/j.jbc.2021.101098Xiaoyu,LuoHugo,Mouquet...
Bystander CD4 T cells do not mediate demyelination in mice infectedsu:旁观者的CD4 T细胞介导的小鼠infectedsu脱髓鞘 文档格式: .pdf 文档大小: 247.21K 文档页数: 9页 顶/踩数: 0/0 收藏人数: 0 评论次数: 0 文档热度: 文档分类: 幼儿/小学教育--教育管理 ...
The results indicated that bystander CD4 T cells were unable to cause demyelination in MHV-infected mice, despite being recruited into the central nervous system (CNS) and irrespective of activation status. These results suggest that CD4 T cells must recognize antigen in the CNS in order to ...
et al. Expression of two T cell receptor α chains: dual receptor T cells. Science 262, 422–424 (1993). Article CAS PubMed Google Scholar Sonntag, K. et al. Immune monitoring and TCR sequencing of CD4 T cells in a long term responsive patient with metastasized pancreatic ductal ...
The results indicated that bystander CD4 T cells were unable to cause demyelination in MHV-infected mice, despite being recruited into the central nervous system (CNS) and irrespective of activation status. These results suggest that CD4 T cells must recognize antigen in the CNS in order to ...
The progressive loss of CD4+T cells during HIV infection of lymphoid tissues involves both the apoptotic death of activated and productively infected CD4 T cells and the pyroptotic death of large numbers of resting and abortively infected bystander CD4 T cells. HIV spreads both through cellular re...
T cells activated in vitro displayed functional receptors for IL-2 and IL-7, suggesting these as potential mediators. This crosstalk between a stimulated CD4 memory T-cell response and CD4 T cells activated by an unrelated antigen could be important in human subjects continually buffeted by ...
The contribution of T cells to the arthritis symptoms that can persist for months or years following antibiotic treatment in patients with Lyme disease are unclear. New evidence from an IL-10-deficient mouse model reveals a role for antigen-independent activation of both CD4 + and CD8 + T ...
The major IFN-γ sources were natural killer (NK) (mean ± SE = 55.2 ± 3.3), CD4+T (24.5 ± 3.3) and CD8+T cells (17.9 ± 1.5), respectively, as demonstrated by four-color flow cytometry. Interestingly, in addition to these cells, we found CsA-resistant IFN-γ producing T cells...