T. Rouse. 1999. Bystander activation of CD4 + T cells can represent an exclusive means of immunopathology in a virus infection. Eur. J. Immunol. 29 3674-3682.Gangappa S, Deshpande SP, Rouse BT. Bystander activation of CD4(+) T cells can represent an exclusive means of immunopathology in...
The contribution of T cells to the arthritis symptoms that can persist for months or years following antibiotic treatment in patients with Lyme disease are unclear. New evidence from an IL-10-deficient mouse model reveals a role for antigen-independent activation of both CD4 + and CD8 + T ...
stimulation14,15. Interestingly, the TCR-independent activation of CD4+T cells has primarily been observed in memory (CD44high) cells, while naïve (CD44low) cells exhibit lower reactivity13,14,15. Thus, it appears that cytokines and innate receptors, such as Toll-like receptors (TLRs), can...
Bystander activation of T cells, i.e. the stimulation of unrelated (heterologous) T cells by cytokines during an Ag-specific T-cell response, has been best described for CD8+ T cells. In the CD8+ compartment, the release of IFN and IFN-inducers leads to the production of IL-15, which ...
These results indicate bystander activation of CD4+ T cells in a virus-induced inflammatory milieu. This mechanism of immunoinflammation may represent an important component of any lesion which involves CD4+ T cells. 展开 关键词: Stromal keratitis Transgenic mouse Immunopathology Bystander activation ...
bystander-activation: 旁观者CD8+ T 细胞的激活及其在病毒感染中的作用。 在病毒感染期间,大量T 细胞以不依赖T 细胞受体和依赖细胞因子的方式被激活,这种现象称为“旁观者激活” genetic signatures for TCR-activation and bystander-activation in T cells ...
However, bystander T-cell activation circumvents the requirement for specific T-cell receptor stimulation, enabling T cells to bypass certain control checkpoints. The physiological relevance of the phenomenon is the subject of much controversy. This article argues that although of little consequence in...
Abrigani S (1997) Bystander activation by cytokines of intrahepatic T cells in chronic viral hepatitis. Semin Liver Dis 17:319–22 Google Scholar McNally JM, Welsh RM (2002) Bystander T cell activation and attrition. Curr Top Microbiol Immunol 263:29–41 ...
This rapid mechanism of CD8(+) T cell activation may be an important component of innate immunity to intracellular pathogens. 展开 关键词: Spleen Killer Cells, Natural CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Cells, Cultured Intracellular Fluid Animals Mice, Inbred C57BL Mice, ...
We have defined the bystander activation of T cells in responses to dengue infection, mediated by IL-12-dependent pathways existing in healthy Thai schoolchildren. These bystander T cells play a major contribute to the IFN-γ production in response to dengue virus in vitro. These immunological re...