(2003) Increased expression of T cell activation markers (CD25, CD26, CD40L and CD69) in atherectomy specimens of patients with unstable angina and acute myocardial infarction. Atherosclerosis 168: 73-80.Hosono M, de Boer OJ, van der Wal AC, van der Loos CM, Teeling P, Piek JJ, et...
We have, therefore, expanded our earlier work by using a panel of different T cell activation markers (CD25, CD26, CD40L, CD69). The study is based on 58 culprit lesions from patients who underwent coronary atherectomy. There were four groups of patients: chronic stable angina ( n=13)...
We found that CD69(+)CD4(+)CD25(-) T cells express membrane-bound TGF-beta1, which mediates suppression of T cell proliferation. Furthermore, engagement of CD69 maintains high expression of membrane-bound TGF-beta1 on CD69(+)CD4(+)CD25(-) T cells via ERK activation. Our results ...
Therefore, we designed a readily soluble and solely proteinaceous T cell activation technology—Expamers, which can be used in closed manufacturing equipment and can be rapidly bound to and removed from the target cell surface, allowing instantaneous initiation and termination of activation signals, res...
In one matched MLR, a combination of T-cell activation markers was used in the APC channel: CD25, CD69, and CD71 APC. 7-AAD was used as a viability marker for all sorts. Flow cytometric cell sorting All sorts were performed with a modified FACS DIVA (BD Pharmingen). Instrument set-up...
结果发现,DCA会降低细胞表面标记物CD69、CD25和CD44,以及颗粒酶B、IFN-γ、TNF等效应因子的表达,从而抑制CD8阳性T细胞的激活和效应功能。 主要结果 进一步,研究人员发现,DCA是CD8阳性T细胞的效应功能的负调节因子,即DCA对CD8阳性T细胞的效应功能的抑制呈现剂量依赖性。而其他次级胆汁酸,如石胆酸(LCA)、牛磺酸脱氧胆酸...
目的探讨寻常性银屑病患者外周血T淋巴细胞激活状态在发病中的作用.方法采用免疫荧光双标记流式细胞术检测32例寻常性银屑病患者外周血CD4+T细胞和CD8+T细胞CD25和CD69的表达,分析其表达水平与疾病严重程度的关系.并对比6例患者进行期和消退期时CD8+T细胞CD25和CD69的表达.结果银屑病患者外周血CD4+T... 查看全部>> ...
目的:初步观察雄黄对MRL/lpr狼疮小鼠SLE动物模型抗双链DNA抗体及T细胞表面分子CD69,CD25表达及其生存时间的影响.方法:将MRL/lpr狼疮小鼠随机分为空白(蒸馏水)对照组,纳米雄黄低中高剂量组,每天灌胃一次,分别在不同时间点采集血清和称重;在实验结束后,取外周淋巴结分离T细胞并体外培养;放射免疫法测定血清抗ds-DNA抗体...
HER2-XPAT protein and unmasked HER2-TCE promoted similar T-cell activation in the tumor microenvironment (TME), indicated by increased expression of activation marker CD25 on both helper and cytotoxic T cells (Fig. 3c). T cells were not activated in peripheral blood where human HER2 is not ...
CD4+CD25+\CD4+CD69+和CD4+HLA-DR+T淋巴细胞的昼夜节律性变化目的:探讨CD4+CD25+、CD4+CD69+和CD4+HLA-DR+T淋巴细胞的昼夜节律性变化情况。方法:10名健康男性志愿者,年龄24～30岁,平均25岁。预先在昼夜节律模式条件(16h-light:8h-darkcycle,LD)下生活1周:室温25±1ºC,起床时间:7:00,睡眠时间(无光...