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摘要原文 A properly functioning immune system is dependent on programmed cell death at virtually every stage of lymphocyte development and activity. This review addresses the phenomenon of activation-induced cell death (AICD) in T lymphocytes, in which activation through the T-cell receptor results in...
However, CAR-T cells are less effective on solid tumors mainly due to the weak persistence of CAR-T cells, which might be caused by T cell death. Significant activation-induced cell death (AICD) of CAR-T cells was triggered by repeated antigen stimulation. AICD of T cell is characterized ...
Activation- induced cell death signalling in CD4+ T cells by staphylococcal enterotoxin A. Toxicol Lett. 2008;176(1):77-84.Porichis F, Morou A, Baritaki S, Spandidos DA, Krambovitis E. Activation-induced cell death signalling in CD4+ T cells by staphylococcal enterotoxin A. Toxicol Lett....
Activation-induced cell death (AICD), which results from the interaction between Fas and Fas ligand, is responsible for maintaining tolerance to self-antigen. A defect in AICD may lead to development of autoimmunity. During the last several years, much progress has been made in understanding the...
Activation-induced cell death (AICD) of T lymphocytes can be exploited by cancers to escape immunological destruction. We demonstrated that tumor-specific cytotoxic T lymphocytes (CTLs) and type 1 helper T (TH1) cells, rather than type 2 helper T cells a
However, CD28-based CAR T cells have a much larger magnitude of phosphorylation that may contribute to activation-induced cell death and early exhaustion compared with the persistence of 4-1BB-based CAR T cells, which have a more memory-like phenotype. PubMed PubMed Central Google Scholar ...
Proliferation and flow cytometry analysis indicated that SEA generated an activation-induced cell death (AICD) phenomenon that was characterized by an increased expression of the chemokine receptor CCR5 on the CD4+/CD45RO+ T cell subset. Incubation of cells with glycoprotein secretion inhibitor ...
Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation. Activation of T cells is induced efficiently by dendritic cells (DC), but little is known about the role of DC in the regulation of T cell death. In this s.....
cells in a state of homeostasis, while also demonstrating the capacity to inhibit activation-induced cell death (AICD). In a study by Lenka et al., co-expressing CAR with a membrane-bound chimeric IL-15 was employed to maintain a long-term memory stem cell phenotype in CAR-T cells [120...