T cell receptors (TCRs) enable T cells to specifically recognize mutations in cancer cells1,2,3. Here we developed a clinical-grade approach based on CRISPR–Cas9 non-viral precision genome-editing to simultaneously knockout the two endogenous TCR genesTRAC(which encodes TCRα) andTRBC(whic...
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在最近发表的Non-viral precision T cell receptor replacement for personalized cell therapy报道了个性化TCR-T细胞工程,利用CRISPR-Cas9技术去除了两条TCRα和TCRβ链,并采用非病毒方法同时插入了新抗原特异性TCR的序列,KI效率达到23%(范围为11.4%~46.8%),并在研究...
该研究成果发表在Nature,以“Non-viral precision T cell receptor replacement for personalized cell therapy”为题目(图1)。研究证实可以使用CRISPR基因编辑来改变免疫细胞,以便它们能够识别特定于人体肿瘤的突变蛋白质。然后可以将这些细胞安全地释放在体内,用以摧毁它们的目标。
Cancer treatments have significantly changed with the introduction of immunotherapy. Recently, the development of new agents that harness the redirection of T-cells against cancer is rapidly emerging in multiple tumor types. Since bispecific T-cell engager (BiTE) therapies have demonstrated clinical benef...
Following their exit from the thymus, T cells are endowed with potent effector functions but must spare host tissue from harm. The fate of these cells is dictated by a series of checkpoints that regulate the quality and magnitude of T cell-mediated immun
aplasia resulting from CD19 CAR T-cell administration is clinically tolerated and made feasible through immunoglobulin replacement therapy [12]. Since then, other CD19 CAR T-cell products, as well as the first non-CD19 directed CAR targeted to B-cell maturation antigen (BCMA) for the treatment...
11月11日,该研究成果发表在Nature,以“Non-viral precision T cell receptor replacement for personalized cell therapy”为题目(图1)。研究证实可以使用CRISPR基因编辑来改变免疫细胞,以便它们能够识别特定于人体肿瘤的突变蛋白质。然后可以...
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