在最近发表的Non-viral precision T cell receptor replacement for personalized cell therapy报道了个性化TCR-T细胞工程,利用CRISPR-Cas9技术去除了两条TCRα和TCRβ链,并采用非病毒方法同时插入了新抗原特异性TCR的序列,KI效率达到23%(范围为11.4%~46.8%),并在研究...
Replacement of a T-cell function by a T-cell product. Nature (Lond.). 237:15.Schimpl, A., and E. Wecker. 1972. Replacement of T-cell function by a T-cell product. Nat. New Biol. 237:15.Schimpl, A., and E. Wecker. 1972. Replacement of T cell function by a T cell product...
Clonal replacement sustains long-lived germinal centers primed by respiratory viruses. Cell 186, 131–146 (2023). Article PubMed Google Scholar Chappert, P. et al. Human anti-smallpox long-lived memory B cells are defined by dynamic interactions in the splenic niche and long-lasting germinal...
胸腺上皮细胞(thymic epithelial cell,TEC)以及其他胸腺基质细胞分泌细胞因子, 如干细胞因子(stem cell factor,SCF)和白细胞介素 -7(interleukin-7,IL-7)等,并表达 Notch 配体 DLL4(Notch ligand delta-like ligand 4,DLL4) 以及主要组织相容性复合体(major...
该研究成果发表在Nature,以“Non-viral precision T cell receptor replacement for personalized cell therapy”为题目(图1)。研究证实可以使用CRISPR基因编辑来改变免疫细胞,以便它们能够识别特定于人体肿瘤的突变蛋白质。然后可以将这些细胞安全地释放在体内,用以摧毁它们的目标。
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Moreover, this also led to the approval of engineered T-cell therapies in patients. Herein, we will expand on the development and the use of such strategies using tumor-infiltrating lymphocytes or genetically engineered T-cells. We will also comment on the requirements and potential hurdles ...
Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don’t respond to immune therapy. Across different tumor types, pre-existing T cell infiltrates predict response to checkpoint-based immuno
Twenty-eight weeks after CAR T-cell infusion, the serum IgG was 388 mg/dL (normal range, 700-1600 mg/dL), the serum IgA was below detectable limits, and the serum IgM was 15 mg/dL (normal range, 40-230 mg/dL). Because of the low immunoglobulin levels, we initiated immunoglobulin ...
Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy, infection and transplantation, patient outcomes are linked to the degree of immune reconstitution, specifically of T cells. Delayed or defective recovery of the T cell pool has significant clinical consequences, inc...