胸腺上皮细胞(thymic epithelial cell,TEC)以及其他胸腺基质细胞分泌细胞因子, 如干细胞因子(stem cell factor,SCF)和白细胞介素 -7(interleukin-7,IL-7)等,并表达 Notch 配体 DLL4(Notch ligand delta-like ligand 4,DLL4) 以及主要组织相容性复合体(major...
(1972) Replacement of T-cell function by a T-cell product. Nature (New Biol.) 237, 15-17.Schimpl, A., Wecker, E.: Replacement of T cell function by a T cell product. Nature 237 , 15 (1972)Schimpl A, Wecker E (1972) Replacement of T cell function by a T cell product. ...
Clonal replacement sustains long-lived germinal centers primed by respiratory viruses. Cell 186, 131–146 (2023). Article PubMed Google Scholar Chappert, P. et al. Human anti-smallpox long-lived memory B cells are defined by dynamic interactions in the splenic niche and long-lasting germinal...
据Nature News消息,近日,美国生物制药公司PACT Pharma等机构的研究团队利用CRISPR/Cas9基因编辑技术对T细胞进行了基因工程改造,使T细胞能够识别单个患者肿瘤中特有的突变蛋白,实现了对实体瘤的特异性治疗。 该研究成果发表在Nature,以“Non-viral precision T cell receptor replacement for personalized cell therapy”为题目...
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Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don’t respond to immune therapy. Across different tumor types, pre-existing T cell infiltrates predict response to checkpoint-based immuno
T cell immunity is central to contemporary cancer and autoimmune therapies, encompassing immune checkpoint blockade and adoptive T cell therapies. Their diverse characteristics can be reprogrammed by different immune challenges dependent on antigen stimu
aplasia resulting from CD19 CAR T-cell administration is clinically tolerated and made feasible through immunoglobulin replacement therapy [12]. Since then, other CD19 CAR T-cell products, as well as the first non-CD19 directed CAR targeted to B-cell maturation antigen (BCMA) for the treatment...
Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy, infection and transplantation, patient outcomes are linked to the degree of immune reconstitution, specifically of T cells. Delayed or defective recovery of the T cell pool has significant clinical consequences, inc...
Following their exit from the thymus, T cells are endowed with potent effector functions but must spare host tissue from harm. The fate of these cells is dictated by a series of checkpoints that regulate the quality and magnitude of T cell-mediated immun