Replacement of T cell function by a T cell product. Nat. New Biol. 237:15.SCHIMPL, A. & WECKER, E. (1972) Replacement of T cell function by a T cell product. Nature, 237, 15.Schimpl A, Wecker E. Replacement of T-cell function by a T-cell product. Nat. New Biol. 1972; ...
T cell receptors (TCRs) enable T cells to specifically recognize mutations in cancer cells1,2,3. Here we developed a clinical-grade approach based on CRISPR–Cas9 non-viral precision genome-editing to simultaneously knockout the two endogenous TCR genesTRAC(which encodes TCRα) andTRBC(whic...
t cell expansion t cell lymphocyte t cell receptor t cell receptor rearr t cell receptortcr t cells t cell subclassificat tcell subgroup t cell subgroups t cell subpopulation t cell subset t cell subsets t cellular subgroup tces transcutaneous c tcfc tcf total coronary fl tcf two colour fluo...
theorymomentum transf theosophic theosophist theoty of cell lineag thepangraspstheboltst thepassivestructureco thepocket-sizeparks thepopulatinbomb theproduct theque organization ther ther income therapeutic community therapeutic counselli therapeutic guide therapeutic of a drug therapeutical food therapeutics...
Cancer treatments have significantly changed with the introduction of immunotherapy. Recently, the development of new agents that harness the redirection of T-cells against cancer is rapidly emerging in multiple tumor types. Since bispecific T-cell engager (BiTE) therapies have demonstrated clinical benef...
B-cell maturation antigen (BCMA) is expressed in most cases of MM. We conducted the first-in-humans clinical trial of chimeric antigen receptor (CAR) T cells targeting BCMA. T cells expressing the CAR used in this work (CAR-BCMA) specifically recognized BCMA-expressing cells. Twelve ...
NB-ROC™ T Cell Serum-Free Media is specially formulated for use with T cells. NB-ROC T significantly boosts ... Quantity: 1 L Features: Serum-Free Supplier PageGet Pricing Compare Product Physiologix™ Xeno-Free Serum Replacement
该研究成果发表在Nature,以“Non-viral precision T cell receptor replacement for personalized cell therapy”为题目(图1)。研究证实可以使用CRISPR基因编辑来改变免疫细胞,以便它们能够识别特定于人体肿瘤的突变蛋白质。然后可以将这些细胞安全地释放在体内,用以摧毁它们的目标。
[5] Chen E L Y, Thompson P K, Zuniga-Pflucker J C. RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymusseeding progenitors[J]. Nat Immunol, 2019, 20(11): 1456-1468. [6] Ceredig R, Rolink A G. The...
Tumor recognition by T cells is essential for antitumor immunity. A comprehensive characterization of T cell diversity may be key to understanding the success of immunomodulatory drugs and failure of PD-1 blockade in tumors such as multiple myeloma (MM). Here, we use single-cell RNA and T cell...