The clonal chromosomal rearrangement t(11;22) has been reported by karyotypic analysis to be specific for Ewing's sarcoma of bone and soft tissue origin as well as primitive neuroectodermal tumour. In this report, immunohistological analysis of MIC 2 expression and fluorescence in situ hybridiz...
Molecular localization of the t(11;22)(q24;q12) translocation of Ewing sarcoma by chromosomal in situ suppression hybridization. Ewing's sarcoma and the related primitive neuroectodermal tumor (PNET) share a unique and specific t(11;22)(q24;q12) chromosomal translocation. The breakpo... L Se...
Cells from the primary tumor and those from the SCCH-196 cell line at passage 10 both showed the same karyotype, 51, XX, + 8, + 20, + 21, t(11;22)(q24;q12), + i(1q), + i(1q). Histologically the primary tumor was difficult to classify as either Ewing's sarcoma (ES) or...
Most Ewing's sarcomas or related primitive neuroectodermal tumors have the chromosomal translocation t(11;22)(q24;q12). Approximately 85% of reported cases of Ewing€s sarcoma bear a EWS/FLI1 fusion. In rare cases, other genes can substitute for EWS or FLI1. Relatively few cases with ...
Location11q24.3 Gene Typeprotein-coding gene Uniprot IDQ01543 Pathway/Libraryothers Gene SummaryThis gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a...
STEAP1 is strongly expressed in >80% of mCRPC with bone or lymph node involvement19, 62% of Ewing sarcoma20, and multiple other cancer types21. STEAP1 belongs to the STEAP family of metalloreductases that can form homotrimers or heterotrimers with other STEAP proteins22. STEAP1 has an ...
Li Z, Yu X, Shen J,Wu WKK,Chan MTV. MicroRNA expression and its clinical implications in Ewing's sarcoma. Cell Prolif; 48(1); 1-6. doi: 10.1111/cpr.12160. Li Z, Yu X, Wang Y, Shen J,Wu WKK, Liang J, Feng F. By downregulating TIAM1 expression, microRNA-329 suppresses gastr...
(kaposi's sarcoma);血管外皮细胞瘤,恶性;淋巴管肉瘤;骨肉瘤;皮质旁骨肉瘤;软骨肉瘤;成软骨细胞瘤,恶性;间胚叶性软骨肉瘤;骨巨细胞瘤;尤因氏肉瘤(ewing'ssarcoma);牙源性肿瘤,恶性;造釉细胞性牙肉瘤;成釉细胞瘤,恶性;造釉细胞性纤维肉瘤;松果体瘤,恶性;脊索瘤;神经胶质瘤,恶性;室管膜瘤;星形细胞瘤;原浆...
[272]. The co-expression of Fas and FasL was observed in brain tumors that can use this mechanism to obtain a proliferating advantage by "counter-attacking" tumor-infiltrating activated Fas-sensitive T lymphocytes [273,274]. Similar observations have been made in Ewing sarcoma [275], gastric ...
Molecular cytogenetic analysis of a complex t(10;22;11) translocation in Ewing's sarcoma. Genes Chromosomes Cancer. 1992 Mar; 4 (2):188–191. [ PubMed ]Speleman F, Van Roy N, Wiegant J. Dierick AM, Uyttendaele D, Leroy JG (1992) Molecular cytogenetic analysis of a complex t(l0...