Immunotherapy has revolutionized cancer treatment, but efficacy remains limited in most clinical settings. Cancer is a systemic disease that induces many functional and compositional changes to the immune system as a whole. Immunity is regulated by inter
Systemic immunityPeripheral blood biomarkersBackground Recent clinical advances in cancer immuno-therapeutics underscore the need for improved understanding of the complex relationship between cancer and the multiple, multi-functional, inter-dependent, cellular and humoral mediators/regulators of the human ...
Systemic immunity adjuvants and their use in cancer treatment. Abstr. Sulfur hexafluoride (SF6) is an excellent tracer of large-scale atmospheric transport, because it has slowly increasing sources mostly confined to northern... AS Denning,M Holzer,KR Gurney,... - Tellus Series B-Chemical & Ph...
Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity. Nat. Cancer 1, 882–893 (2020). CAS PubMed PubMed Central Google Scholar Liu, J. Q. et al. Intratumoral delivery of IL-12 and IL-27 mRNA using lipid ...
Systemic immune activity predicts overall survival in treatment-naive ... Mikhail,Sameh,Lesinski,... - 《Clinical Cancer Research An Official Journal of the American Association for Cancer Research》 被引量: 0发表: 2016年 Perioperative Enteral Immunonutrition Modulates Systemic and Mucosal Immunity and...
Tlr3 and tlr4 as potential clinical biomarkers for in-stent restenosis in drug-eluting stents patients. Immunol Res. 2016;64:424–30. https://doi.org/10.1007/s12026-015-8685-6. Article CAS PubMed Google Scholar Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat...
As these two molecules are potent stimulators of T helper (Th)1 type immunity, such exosomes have the potential to stimulate immune activation. In cancer, DCs are commonly immature due to the suppressive TME. Since immature DCs lack or have low expression of co-stimulatory molecules and a ...
Immunosuppressive drugs successfully prevent rejection of islet allografts in the treatment of type I diabetes. However, the drugs also suppress systemic immunity increasing the risk of opportunistic infection and cancer development in allograft recipients. In this study, we investigated a new treatment fo...
1.3 Systemic plant immunity 1.3.1 Systemic acquired resistance In plants, localized pathogen attack, whether inducing an HR or moderate symptoms of disease, often elicits broad-spectrum immunity to reinfection throughout the whole body. This type of systemic plant immunity is called systemic acquired ...
Radiation therapy for cancer can lead to off-target toxicity and can be ineffective against hypoxic solid tumours and distant metastases. Here, we show that intratumoral injection, in mouse and rabbit xenografts and in patient-derived mouse xenografts, of a sodium alginate formulation containing catala...