From the review above, key findings emerged regarding potential functions of inhibitory and costimulatory immune checkpoints targeting the metastatic cascade and point towards novel potential Achilles' heels of cancer that might be exploited therapeutically in the future.doi:10.1007/s00262-020-02717-2Ali SafarzadehMohsen AlizadehFatemeh ...
Vol 5. Cancer. London: Plenum Press, 1983:217-252.Varesio, L (1983) Suppressor cells and cancer: Inhibition of immune functions of macrophages. The Reticuloendothelial System: A Comprehensive Treatise 5: pp. 217-252Varesio, L. 1983, Suppressor cells and cancer: Inhibition of immune ...
Finally, CAR T cells are grown on the scale of days in bioreactors and then delivered back to patients for infusion. Typically, CAR T cells are given as a single dose, or sometimes split over 2 or 3 days; regardless, this is still substantially different from most cancer drugs, which...
Tumor-associated macrophages (TAMs), one of the most abundant immune subsets in the tumor microenvironment (TME), have been shown to modulate the formation of an immunosuppressive TME and impair host antitumor responses through pro-tumorigenic activities1,2. Reeducation of TAMs by targeting cytokine ...
Current cancer therapies are designed to target the TGF-β signaling pathway primarily in the tumor. We propose that therapies that also counteract the immunosuppressive effects of TGF-β and incorporate restoration of the host immune response may help achieve tumor eradication. Introduction Malfunctions...
Meanwhile, the activation of STAT3 in the metastatic foci is attenuated and the immunosuppressive microenvironment is reversed. This study demonstrates that SIL@T with dual immunomodulatory functions provides a promising immune synergistic therapy strategy for breast cancer brain metastases. Graphical abstract...
As one of the most abundant immune cell types in the TME, tumor-associated macrophages (TAMs) account for approximately 50% of the local hematopoietic cells. TAMs secrete various biological factors, such as inflammatory cytokines, chemokines, growth factors, and exosomes, and they influence cancer ...
To study the biological function of IL-1Ra in tumors, we generated a set of mouse pancreatic cancer cell lines with a knockout (KO) of the Il1rn gene, encoding IL-1Ra, and compared the tumor growth rates in immune-competent and immune-deficient mice. We found that the Il1rn KO cells...
Cancer: Facts about the diseases that cause out-of-control cell growth The primary organs of the urinary system are the kidneys, which are bean-shaped organs that are located just below the rib cage in the middle of the back. The kidneys remove urea — waste product formed by the breakdo...
Endometrial cancer (EC) is the most common gynecological malignancy worldwide. However, the molecular mechanisms underlying EC progression are still largely unknown, and chemotherapeutic options for EC patients are currently very limited. In this study,