CAR）工程应用于自体 T 细胞，开创了合成癌症免疫（synthetic immunity to cancer）的先河。CAR...
CancerImmunityQTL数据库整合了GWAS,eQTL,RNA-seq数据,用户可以查询SNP位点在泛癌中与免疫细胞的浸润、对患者生存的影响和与其他表型的作用。CancerImmunityQTL数据库弥补了遗传变异在泛癌中作用的空白。 END
Cancer-Immunity Cycle:肿瘤免疫循环简介 免疫系统是防止病原体入侵, 维持机体内环境稳定的有效武器,免疫系统由免疫器官(骨髓,胸腺,脾脏,淋巴结等),免疫细胞(淋巴细胞, 单核巨噬细胞等)和免疫活性物质(抗体,白细胞介素等)组成。 人体的免疫系统包含3道防线,第一道是皮肤和粘膜,第二道是吞噬细胞,杀伤细胞等固有免...
肿瘤免疫循环（cancer-immunity cycle）的概念由Ira Mellman和Daniel S. Chen于 2013 年提出，阐述了一...
However, elimination of cancer by T cells is only one step in the Cancer-Immunity Cycle, which manages the delicate balance between the recognition of nonself and the prevention of autoimmunity. Identification of cancer cell T cell inhibitory signals, including PD-L1, has prompted the development...
数据库解析01 Web界面 我们可以直接登录癌症免疫QTL网站 (http://www.cancerimmunityqtl-hust.com/#/), 无需注册。CancerImmunityQTL 提供三个模块的数据浏览和查询: 免疫QTL、免疫QTL 生存分析 、GWAS-免疫QTL。每一个模块都可以分为"单一搜索"和"批量搜索"两种查询模式。 02 ImmunQTL模块 免疫QTL模块主要查询不...
The Cancer-Immunity Cycle What is tumor mutation load? Why does the immune repertoire matter? Introduction Cancer is a disease where genetic mutation has resulted in changes in normal regulatory processes, causing cells to grow out of ...
(TIME).2,3And accordingly, promoting the transition from a pro-tumor to an anti-tumor effect to maximize the efficacy of anti-tumor immunity is a main goal of immunotherapy.4,5Recent tumor immunotherapy strategies, such as immune checkpoint blockades (ICBs), cancer vaccines, and adoptive cell...
Figure 1. The Cancer-Immunity Cycle In cancer patients, the cycle is not operating properly. For example, tumor antigens may not be detected correctly by dendritic cells, or the tumor microenvironment might suppress the effector cells that ...
Cancer 76: 824–832 PubMed CAS Google Scholar Walter EA, Greenberg PD, Gilbert MJ, Finch RJ, Watanabe KS, Thomas ED, Riddell SR (1995) Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J...