SLC7A11是一种多次跨膜蛋白,可导入胱氨酸以进行GSH生物合成和抗氧化防御,SLC3A2是一种单跨膜蛋白,具有维持SLC7A11蛋白的稳定性并向胞膜运输的作用,其功能不仅限于胱氨酸转运,还转运多种氨基酸蛋白[26],二者是合成GSH的重要参与蛋白[27]。激活System Xc-可以促进细胞内胱氨酸的摄取并将其还原为半胱氨酸,半胱氨...
由系统XC-胱氨酸,谷氨酸转运(由slc7a11编码)。 翻译结果2复制译文编辑译文朗读译文返回顶部 按系统 xc cystine 谷氨酸盐的运输机 ( 将编码通过 Slc7a11 )。 翻译结果3复制译文编辑译文朗读译文返回顶部 由系统 xc− 胱氨酸-谷氨酸转运体 (由 Slc7a11 编码)。
Evidence has shown that ferroptosis is crucial for DCM pathogenesis [48]. Wang et al. elucidated that sulforaphane restored the downregulation of SLC7A11/GSH, suppressed ferroptosis, and improved cardiac function by activating the AMPK/Nrf2 pathway in the myocardium of type 2 diabetic mice [48]. ...
Evidence has shown that ferroptosis is crucial for DCM pathogenesis [48]. Wang et al. elucidated that sulforaphane restored the downregulation of SLC7A11/GSH, suppressed ferroptosis, and improved cardiac function by activating the AMPK/Nrf2 pathway in the myocardium of type 2 diabetic mice [48]. ...
如图8所示,与对照组比较,模型组大鼠胰腺组织中SLC3A2、SLC7A11、GCLM、GSS和GPX4蛋白表达显著降低(P<0.001),ACSL4蛋白表达显著升高(P<0.001);与模型组比较,卡格列净组和白术内酯I高剂量组SLC3A2、SLC7A11、GCLM、GSS和GPX4蛋白表达...
01 通过抑制system xc-诱导铁死亡 system xc-广泛分布在磷脂双层中。它是细胞中重要抗氧化系统的一部分,是由SLC7A11和SLC3A2两个亚基组成的异二聚体。胱氨酸和谷氨酸通过系统Xc-以1:1的比例交换进出细胞,被吸收的胱氨酸在细胞中还原为半胱氨酸,其参与GSH的合成。GSH在谷胱甘肽过氧化物酶(GPXs)的作用下降低ROS。
Slc7a11 (xCT) protein expression is not altered in the depressed brain and system xc- deficiency does not affect depression-associated behaviour in the cor... xCT protein expression is not altered in the depressed brain and system xc- deficiency does not affect depression-associated behaviour in...
The solute carrier family 7 (anionic amino acid transporter light chain, xc-system), member 11 (SLC7A11) gene in the interferon pathway, reported to ... Hamid,Shahrul - 《International Journal of Molecular Medicine》 被引量: 32发表: 2014年 A Novel Transcription Mechanism Activated by Ethanol...
System xc-xCTExtracellular glutamateMouse behaviorAbstractThe slc7a11 gene encodes xCT, an essential component of ‘system xc-’, a plasma membrane exchanger that imports cystine and exports glutamate. Slc7a11 is expressed primarily in the brain, but its role there is not clear. We performed ...
However, no particular behavioral deficits were shared by both mutant strains and their F1 offspring, forcing us to conclude that the behavioral differences that we observed are not attributable to loss of system xc-. To ensure that the differences between slc7a11 mutant strains were not due to...