Standard algorithm [6][11] Initial test: NTT Positive NTT: Perform a TT. Negative NTT: Further management depends on risk status; see “Overview of syphilis testing algorithms.” Second test: TT Positive TT: Current or past syphilis infection is likely; see “Overview of syphilis testing...
The article discusses research which examined the prevalence of syphilis serology testing algorithm among laboratory participants in the College of American Pathologists proficiency testing program. The study surveyed the prevalence in the use of reverse-sequence algorithm, traditional algorithm and individual...
Reverse sequence algorithmTraditional algorithmPotential organ and tissue donors are tested to detect infection with T. pallidum, the etiologic agent of syphilis. Important considerations for testing potential donors include available specimen type and volume, turnaround time, and ability to distinguish ...
18.Soreng K, Levy R, Fakile Y. Serologic testing for syphilis: Benefits and challenges of a reverse algorithm. Clinical Microbiology Newsletter. 2014;36(24):195-202. DOI: 10.1016/j.clinmicnews.2014.12.001 19.Harman LE, Margo CE, Roetzheim RG. Uveitis: The collaborative diagnostic evaluation...
In this study, we used the traditional syphilis testing algorithm with an initial screening with nontreponemal test, followed by a confirmatory treponemal test. The reverse testing algorithm, which first uses a treponemal test, has advantages (Dunseth et al., 2017) and has been adopted in many ...
Reinfection rates among MSM are high, so frequent serological testing in this group is recommended. CDC recommends the use of the RPR-based screening algorithm. When there is a low epidemiologic risk or clinical probability of syphilis, the positive predictive value of an isolated unconfirmed reactiv...
A positive titer with a VDRL or RPR indicatesactive syphilis and follow-up serologic testing is performed to monitor treatment response. With this new testing algorithm that uses the treponemal test first, some patients may test positive for a treponemal test but test negative with a nontreponemal...
There is no agreed protocol for serological investigation of syphilis. However, the traditional algorithm involves a combination of non-treponemal and treponemal tests, followed-up with a treponemal test of similar sensitivity and specificity in positive cases.20Where positive cases are detected, repeat...
TP assay is intended to be used as an initial diagnostic test or in conjunction with a nontreponemal laboratory test and clinical findings to aid in the diagnosis of syphilis infection.See Important Safety Information on Reverse ARCHITECT SYPHILIS TP TRADITIONAL ALGORITHM 3REVERSE ALGORITHM 3
At the laboratory, they test for syphilis using either the traditional or the reverse testing algorithms29. With the reverse testing algorithm, the laboratory screens the serum specimen using a specific treponemal test (TPAb) and confirms the treponemal infection using the rapid plasma reagin test (...