An increasing number of institutions are transitioning from the traditional syphilis testing algorithm (initial screening with nontreponemal tests) to the 'reverse' algorithm (initial screening with treponemal tests such as syphilis IgG). The aim of this study was to evaluate the switch in syphilis ...
Context: -Syphilis serology screening in laboratory practice is evolving. Traditionally, the syphilis screening algorithm begins with a nontreponemal immunoassay, which is manually performed by a laboratory technologist. In contrast, the reverse algorithm begins with a treponemal immunoassay, which can be...
ECDC-recommended algorithmBackground. Two serologic syphilis screening algorithms recommended by the US Centers for Disease Control and Prevention (US CDC) and the European Centre for Disease Prevention and Control (ECDC), respectively, are commonly used for syphilis screening; however, which one is ...
ECDC-recommended algorithmBackground. Two serologic syphilis screening algorithms recommended by the US Centers for Disease Control and Prevention (US CDC) and the European Centre for Disease Prevention and Control (ECDC), respectively, are commonly used for syphilis screening; however, which one is ...
Reverse algorithmPublished studies show that >99% of sera reactive in the reverse syphilis testing algorithm (RSTA) screening assay with an index above an assay-specific threshold confirm as reactive, with either a rapid plasma reagin-reactive (RPRR) or RPR-nonreactive/Treponema pallidum particle ...
Reverse Sequence Syphilis Testing: Pros and Cons of Syphilis Screening with EIAT. Peterman
Furthermore, low-barrier treponemal testing as a first step in the reverse algorithm may increase syphilis screening and decrease time to treatment.doi:10.1097/OLQ.0000000000001955Menza, Timothy W. MD, PhDBerry, Stephen A. MD, PhDDombrowski, Julia C. MD, MPH...
Rhoads DD, Genzen JR, Bashleben CP, Faix JD, Ansari MQ. 2017. Preva- lence of traditional and reverse-algorithm syphilis screening in labora- tory practice: a survey of participants in the College of American Pathol- ogists Syphilis Serology Proficiency Testing Program. Arch Pathol Lab Med...
Reverse sequence algorithmserologySyphilisBackground Recent recommendations propose that serum samples reactive by both syphilis enzyme immunoassay (EIA) or chemoluminescent immonoassay (CLIA) and RPR may not need treponemal confirmatory testing. There is uncertainty regarding the confirmation rate of EIA/...
Reverse screening for syphilis using specific test like chemiluminescence immunoassay (CLIA) allows automation for high sample load testing, followed by testing of positive sera with a non-treponemal. In case of discordant result between the two tests, the sample is tested with another confirmatory ...