A synthetic glycolate metabolism bypass in rice chloroplasts increases photosynthesis and yieldPhotorespiratory bypassPhotosynthetic EfficiencyCrop YieldRicePhotorespiration consumes photosynthetically fixed ca
R. Synthetic glycolate metabolism pathways stimulate crop growth and productivity in the field. Science 363, eaat9077 (2019). Article CAS PubMed Google Scholar Kubis, A. & Bar-Even, A. Synthetic biology approaches for improving photosynthesis. J. Exp. Bot. 70, 1425–1433 (2019). Article...
Uncontrolled drainage of pathway intermediates through other reactions, especially by enzymes in central carbon metabolism may also limit pathway activity. It is therefore important to analyze the compatibility of the novel pathways with endogenous metabolism before the in vivo implementation stage; this ...
The C1-metabolism of methylotrophic yeasts compared to bacteria differs primarily in the recruited enzymes, energy generation and carbon assimilation pathways. In general, methanol is oxidized to formaldehyde, which then can be diverted to either assimilatory (product biomass) or dissimilatory (product ...
High production of 3-hydroxypropionic acid in Klebsiella pneumoniae by systematic optimization of glycerol metabolism. Sci Rep. 2016;6:26932. Article CAS Google Scholar Choi SY, Park SJ, Kim WJ, Yang JE, Lee H, Shin J, Lee SY. One-step fermentative production of poly(lactate-co-glycolate...
(product CO2) pathways (Fig.2). Formaldehyde plays a pivotal role in the metabolism of methylotrophic organisms for various reasons. Precisely, (I) formaldehyde is generated mainly from methanol in the cell; (II) this molecule depicts the branch point between C1-assimilation and dissimilation in...
This green sulfur bacterium uses the 3-hydroxypropionate bicycle in combination with the glyoxylate cycle to channel organic substrates such as glycolate, acetate, propionate, 3-hydroxypropionate, lactate, butyrate, or succinate for its central carbon metabolism under both autotrophic and heterotrophic ...
A huge disadvantage is that all of the carbon is lost instead of ‘only’ one out of four, as in the other pathways. When experimentally realized by redirecting peroxisomal glycolate oxidase and catalase to the chloroplast, transgenic A. thaliana were demonstrated to support higher dry weight ...